caa a22 4500 469116862 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00170943 doi (NATIONALLICENCE)springer-10.1007/BF00170943 P-glycoprotein expression in brain tumors [Elektronische Daten] [John Henson, Carlos Cordon-Cardo, Jerome Posner] Summary: Overexpression of P-glycoprotein (P-gp) in cancer cells can result in resistance to several chemotherapy agents (multidrug resistance) including doxorubicin and vincristine. The drugs to which resistance develops also penetrate the blood brain barrier poorly. P-gp expression in brain capillary endothelial cells suggests that P-gp may restrict drug entry into brain tumors and thus be another mechanism of drug resistance. To seek evidence for either of these roles in the drug resistance of brain tumors, we examined the location of expression of P-gp in 49 brain tumors, using an anti-P-gp mouse monoclonal antibody and immunohistochemistry. P-gp expression was observed in tumor cells of two glioblastomas and a meningeal sarcoma but not in low-grade primary or metastatic tumors. In low-grade primary tumors, P-gp was present in all vascular endothelial cells. In the vascular endothelial cells of anaplastic primary brain tumors and brain metastases, P-gp expression was heterogeneous or absent. These findings are consistent with a role for P-gp in the resistance of some brain tumors to chemotherapy agents. Kluwer Academic Publishers, 1992 P-glycoprotein nationallicence multidrug resistance nationallicence brain tumor nationallicence immunohistochemistry nationallicence Henson John Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Cordon-Cardo Carlos Department of Pathology Cancer Center, New York, NY, USA aut Posner Jerome Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 37-43 0167-594X 14:1<37 1992 14 11060 https://doi.org/10.1007/BF00170943 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00170943 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Henson John Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Cordon-Cardo Carlos Department of Pathology Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Posner Jerome Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 37-43 0167-594X 14:1<37 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer