caa a22 4500 469116870 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00170944 doi (NATIONALLICENCE)springer-10.1007/BF00170944 Childhood brain tumors that occupy more than one compartment at presentation [Elektronische Daten] Multiple compartment tumors [F. Gilles, A. Leviton, E. Hedley-Whyte, E. Sobel, C. Tavaré, R. Sobel, L. Rorke] Children whose brain tumor involves two or more compartments at presentation differ clinically and pathologically from children whose brain tumor is confined to one compartment. In this study of 3,291 children with a brain tumor, at least 10% had a tumor that occupied two or three compartments at first hospitalization. Infratentorial tumors occupying multiple compartments were 1.7 times more likely to involve the cervicomedullary junction than the mesodiencephalic junction. Younger children (1-3 years) were more likely to have had multiple compartment tumors than older children. Children whose tumor was limited to the infratentorial compartment had a longer survival than children whose tumor also occupied other compartments. Ependymoma, anaplastic ependymoma, and astrocytoma (nos) were over represented among infratentorial multiple compartment tumors. Pilocytic astrocytoma, primitive neuroectodermal tumor (medulloblastoma), and desmoplastic medulloblastoma were less likely to have occupied multiple compartments at the time of the first surgical exploration. The distributions of histologic features in tumors at the cervicomedullary junction differed from those in tumors limited to the posterior fossa or to the spinal canal. Seizures were more likely if the tumor was confined to the supratentorial compartment, whereas nausea or vomiting and headache were more likely if the tumor was confined to the infratentorial compartment. Children whose tumor was confined to the spinal canal were significantly more likely to have bladder symptoms and back and/or abdominal pain than those whose tumor also involved compartments above the foramen magnum. We conclude that brain tumors apparently confined to one compartment at presentation are biologically and structurally different from tumors evident in two or more compartments. Kluwer Academic Publishers, 1992 supratentorial tumors nationallicence infratentorial tumors nationallicence spinal cord tumors nationallicence survival nationallicence outcome nationallicence intracranial nationallicence intraspinal nationallicence childhood brain tumors nationallicence Gilles F. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut Leviton A. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut Hedley-Whyte E. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut Sobel E. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut Tavaré C. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut Sobel R. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut Rorke L. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 45-56 0167-594X 14:1<45 1992 14 11060 https://doi.org/10.1007/BF00170944 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00170944 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gilles F. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Leviton A. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Hedley-Whyte E. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Sobel E. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Tavaré C. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Sobel R. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Rorke L. Childhood Brain Tumor Consortium, Childrens Hospital of Los Angeles, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 45-56 0167-594X 14:1<45 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer