caa a22 4500 469116889 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00170941 doi (NATIONALLICENCE)springer-10.1007/BF00170941 Intraneoplastic application of metrizamide containing liposomes: kinetic studies with computed tomography [Elektronische Daten] [Berndt Wowra, Karsten Cremer, Herbert Stricker, W. Zeller] Summary: Liposomes may serve as drug carriers not only for systemic chemotherapy but also for intraneoplastic drug therapy because they show a sustained drug release. In the present study, the in vivo kinetics of intraneoplastic deposits of large multilamellar vesicles containing metrizamide was followed up in a rat tumor model with computed tomography. The influence of four different lipid compositions on the retardation capacity of large multilamellar liposomes was investigated. By comparing the dynamic data of X-ray attenuation and volume of liposome deposits, a rank order for the in vivo stability of metrizamide containing multilamellar vesicles could be established: the least stable liposomes were made of pure dimyristoyl-phosphatidyl-choline, the most stable type was made of equimolar parts of stearoyl-palmitoyl-phosphatidyl-choline and cholesterol. Of intermediate stability were liposomes made of equimolar parts of dimyristoyl-phosphatidyl-choline and cholesterol, and those made of pure stearoyl-palmitoyl-phosphatidyl-choline. The addition of 50% cholesterol increased the membrane stability of both dimyristoyl-phosphatidyl-choline and stearoyl-palmitoyl-phosphatidyl-choline liposomes. No diffusion of large multilamellar liposomes away from the injection site was observed. The in vivo stability of the liposomes was considerably less than that observed in vitro, suggesting active degradation processes. It is concluded that large, multilamellar liposomes may be suitable carriers for intraneoplastic chemotherapy. The present model is easily adaptable to be transferred into clinical conditions, and may allow direct monitoring of intraneoplastic liposome-mediated chemotherapy in human brain tumors. Kluwer Academic Publishers, 1992 multilamellar vesicles nationallicence intraneoplastic application nationallicence CT kinetics nationallicence rat glioma nationallicence Wowra Berndt Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany aut Cremer Karsten Institute of Pharmaceutical Technology and Biopharmaceutics, Heidelberg, Germany aut Stricker Herbert Institute of Pharmaceutical Technology and Biopharmaceutics, Heidelberg, Germany aut Zeller W. German Cancer Research Center, Heidelberg, Germany aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 9-18 0167-594X 14:1<9 1992 14 11060 https://doi.org/10.1007/BF00170941 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00170941 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wowra Berndt Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany aut NATIONALLICENCE 700 1- Cremer Karsten Institute of Pharmaceutical Technology and Biopharmaceutics, Heidelberg, Germany aut NATIONALLICENCE 700 1- Stricker Herbert Institute of Pharmaceutical Technology and Biopharmaceutics, Heidelberg, Germany aut NATIONALLICENCE 700 1- Zeller W. German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 9-18 0167-594X 14:1<9 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer