caa a22 4500 469116897 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00170947 doi (NATIONALLICENCE)springer-10.1007/BF00170947 Combined intra-arterial chemotherapy followed by radiation in astrocytomas [Elektronische Daten] [Kjell Watne, Einar Hannisdal, Ole Nome, Bjarne Hager, Knut Wester, Mona Heier, Henry Hirschberg] Summary: Seventy-five patients harboring astrocytomas received 4 cycles of infra-ophtalmic carotid injections of BCNU, combined with vincristine intravenously and procarbazine orally. All of the patients thereafter, received radiation therapy. The five year survival was 73% for all patients. The age of the patients had no significant impact on survival. The treatment results were compared with the results of 57 patients with astrocytomas who were treated with surgery followed by radiation in the same period. These 57 patients had a 5 year survival of 45% with a five year survival in patients >- 40 years and patients < 40 years of 70% and 22%, respectively (p < 0.05). In multivariate survival analysis of the BCNU group and radiation group together, treatment group and corticosteroid dependency were the only prognostic factors. No leukoencephalopathy was seen during the treatment or in the follow-up of the patients. We conclude that pre-radiation infra-arterial chemotherapy can be given without significant morbidity and produces an improvement in survival in patients older than 40 years. Kluwer Academic Publishers, 1992 intracarotid chemotherapy nationallicence BCNU nationallicence astrocytoma nationallicence radiation nationallicence Watne Kjell Department of Medical Oncology and Radiology, The Norwegian Radium Hospital, Oslo, Norway aut Hannisdal Einar Department of Medical Oncology and Radiology, The Norwegian Radium Hospital, Oslo, Norway aut Nome Ole Department of Medical Oncology and Radiology, The Norwegian Radium Hospital, Oslo, Norway aut Hager Bjarne Department of Medical Oncology and Radiology, The Norwegian Radium Hospital, Oslo, Norway aut Wester Knut Department of Neurosurgery, The National Hospital, Oslo, Norway aut Heier Mona Department of Neurology, Ullevdl Hospital, Oslo, Norway aut Hirschberg Henry Department of Neurosurgery, The National Hospital, Oslo, Norway aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 73-80 0167-594X 14:1<73 1992 14 11060 https://doi.org/10.1007/BF00170947 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00170947 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Watne Kjell Department of Medical Oncology and Radiology, The Norwegian Radium Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Hannisdal Einar Department of Medical Oncology and Radiology, The Norwegian Radium Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Nome Ole Department of Medical Oncology and Radiology, The Norwegian Radium Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Hager Bjarne Department of Medical Oncology and Radiology, The Norwegian Radium Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Wester Knut Department of Neurosurgery, The National Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Heier Mona Department of Neurology, Ullevdl Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Hirschberg Henry Department of Neurosurgery, The National Hospital, Oslo, Norway aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 73-80 0167-594X 14:1<73 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer