caa a22 4500 469116927 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00170948 doi (NATIONALLICENCE)springer-10.1007/BF00170948 Metabolic changes of glioma following chemotherapy: an experimental study using four PET tracers [Elektronische Daten] [Kiyotaka Sato, Motonobu Kameyama, Kiichi Ishiwata, Ryuichi Katakura, Takashi Yoshimoto] Summary: To shed light on the metabolic changes in glioma following therapy, uptake changes among 18F-fluoro-2′-deoxyuridine (18FUdR), 14C-thymidine (dThd),14C-methionine (Met) and 3H-deoxyglucose (DG) in glioma model after chemotherapy were studied, as a means for interpreting clinical PET results, together with the changes in the bromodeoxyuridine (BUdR) labeling index. 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(-2 chloroethyl)-3-nitrosourea hydrochloride (ACNU) was administered intraperitoneally in the tumor-bearing rats and uptake of the tracers or BUdR labeling index in tumor tissue were measured. The metabolic response following chemotherapy was a sharp fall immediately for 14C-dThd and 18FUdR and a moderate fall for 14C-Met whereas there was a fall in 3H-DG from 1 week after chemotherapy. The changes of BUdR labeling index paralleled that in the uptake for dThd and FUdR. These result indicate that PET scans using a variety of tracers in conjunction could be used for clinical diagnosis and evaluation of therapy in glioma cases. 18FUdR is a promising tracer of nucleic acid metabolism to evaluate the proliferative potential of brain gliomas. Kluwer Academic Publishers, 1992 18F-fluoro-2′-deoxyuridine nationallicence rat glioma nationallicence PET nationallicence bromodeoxyuridine nationallicence Sato Kiyotaka Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Japan aut Kameyama Motonobu Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Japan aut Ishiwata Kiichi Division of Radiopharmaceutical Chemistry, Cyclotron and adioisotope Center, Tohoku University, Japan aut Katakura Ryuichi Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Japan aut Yoshimoto Takashi Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Japan aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 81-89 0167-594X 14:1<81 1992 14 11060 https://doi.org/10.1007/BF00170948 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00170948 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sato Kiyotaka Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Japan aut NATIONALLICENCE 700 1- Kameyama Motonobu Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Japan aut NATIONALLICENCE 700 1- Ishiwata Kiichi Division of Radiopharmaceutical Chemistry, Cyclotron and adioisotope Center, Tohoku University, Japan aut NATIONALLICENCE 700 1- Katakura Ryuichi Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Japan aut NATIONALLICENCE 700 1- Yoshimoto Takashi Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Japan aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 81-89 0167-594X 14:1<81 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer