caa a22 4500 469116943 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00170945 doi (NATIONALLICENCE)springer-10.1007/BF00170945 Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy [Elektronische Daten] [Ammar Hayani, Donald Mahoney Jr., Linda Taylor] Between 1978 and 1988, 20 children with medulloblastoma (MB) of the brain were treated postoperatively with MOPP (nitrogen mustard, vincristine, prednisone, and procarbazine). All but one received post-operative radiation prior to MOPP. Eight of 20 patients remained in continuous complete remission from MB, two of whom eventually developed myelodysplastic syndrome (MDS). Following resection of MB at age 12 months, one patient was treated with 24 courses of MOPP over 2 years without radiation therapy. She developed pancytopenia, and MDS was diagnosed 19 months after the completion of MOPP. Analysis of unstimulated bone marrow (BM) chromosomes showed structural abnormalities involving chromosomes 7, 10, 17, and 21. Eight months later, MDS evolved into acute myeloid leukemia. The second patient was diagnosed with MB at age 7 years and received postoperative craniospinal radiation followed by 12 courses of MOPP over one year. Five months after completion of MOPP, she developed MDS with monosomy 7 on chromosome analysis of bone marrow cells. Therapy-related MDS may be a complication of MOPP chemotherapy for MB in young children. Kluwer Academic Publishers, 1992 medulloblastoma nationallicence MOPP nationallicence myelodysplastic syndrome nationallicence second malignancy nationallicence monosomy 7 nationallicence Hayani Ammar Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA aut Mahoney Jr. Donald Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA aut Taylor Linda Department of Pathology, Baylor College of Medicine, Houston, TX, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 57-62 0167-594X 14:1<57 1992 14 11060 https://doi.org/10.1007/BF00170945 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00170945 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hayani Ammar Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA aut NATIONALLICENCE 700 1- Mahoney Jr Donald Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA aut NATIONALLICENCE 700 1- Taylor Linda Department of Pathology, Baylor College of Medicine, Houston, TX, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/1(1992-09-01), 57-62 0167-594X 14:1<57 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer