caa a22 4500 469116951 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00172603 doi (NATIONALLICENCE)springer-10.1007/BF00172603 Primary central nervous system lymphoma: a role for adjuvant chemotherapy [Elektronische Daten] [Marc Chamberlain, Victor Levin] Summary: Sixteen immunocompetent patients, 10 of whom were previously reported, with primary non-Hodgkins lymphoma of the central nervous system (PCNSL) were treated and followed longitudinally by the Neurooncology Service at the University of California, San Francisco (UCSF) and the University of California, San Diego (UCSD). After undergoing surgery (biopsy or resection), these patients received radiation therapy (RT) with hydroxyurea (HU) followed by adjuvant chemotherapy with the combination of procarbazine, CCNU, and vincristine (PCV) as previously reported. All patients ultimately died of progressive recurrent PCNSL. Toxicity using the HU + RT followed by PCV schedule was tolerable. Median and quartile survival data (41 and 65 months, respectively) suggest efficacy for this chemotherapy schedule and further emphasizes a role for adjuvant chemotherapy in the primary treatment of PCNSL. Kluwer Academic Publishers, 1992 adjuvant chemotherapy nationallicence CNS nationallicence lymphoma nationallicence primary nationallicence Chamberlain Marc Brain Tumor Research Center, Department of Neurological Surgery, University of California School of Medicine, 94143, San Francisco, San Francisco, California, USA aut Levin Victor Brain Tumor Research Center, Department of Neurological Surgery, University of California School of Medicine, 94143, San Francisco, San Francisco, California, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/3(1992-11-01), 271-275 0167-594X 14:3<271 1992 14 11060 https://doi.org/10.1007/BF00172603 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172603 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chamberlain Marc Brain Tumor Research Center, Department of Neurological Surgery, University of California School of Medicine, 94143, San Francisco, San Francisco, California, USA aut NATIONALLICENCE 700 1- Levin Victor Brain Tumor Research Center, Department of Neurological Surgery, University of California School of Medicine, 94143, San Francisco, San Francisco, California, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/3(1992-11-01), 271-275 0167-594X 14:3<271 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer