caa a22 4500 469117001 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00172600 doi (NATIONALLICENCE)springer-10.1007/BF00172600 Quality of life self-reports from 200 brain tumor patients: comparisons with Karnofsky performance scores [Elektronische Daten] [Norman Mackworth, Patricia Fobair, Michael Prados] Summary: To test a method of assessing quality of life, 200 primary brain tumor patients in an outpatient clinic answered a 20-minute questionnaire covering ten aspects of quality of life. These results were compared with Karnofsky performance scale (KPS) scores, taking age into account. Among patients with KPS 90-100 (two-thirds of the patients), the KPS alone was difficult to interpret. The questionnaire, with its specific questions related to the key dimension of well-being, provided a more definitive assessment of status. The central importance of well-being was supported by its strong statistical relationships with other dimensions. Particularly, well-being was related to freedom from depression (p < 0.0001), active social life (p < 0.0001), energy (p < 0.01), and fewer symptoms (p < 0.05). The KPS was more useful in differentiating the other one-third of the patients (KPS 50-80) but was highly sensitive to age. KPS scores, therefore, may have been unreliable. Depression, reported by half of the patients, was not predicted by the KPS when age was excluded from the regression analysis but was related to the scores in well-being and socializing. Neither depression, well-being, nor socializing was influenced by age. Thus, the questionnaire directly assessed these central, emotionally based variables, particularly among patients with satisfactory KPS. Such an assessment is especially crucial as a supplement to the KPS in evaluating brain tumor survivors, whose emotional well-being is often severely challenged by treatment after surgical excision. Kluwer Academic Publishers, 1992 Karnofsky performance scale nationallicence quality of life nationallicence brain tumors nationallicence depression nationallicence Mackworth Norman Neuro-Oncology Service, Brain Tumor Research Center, Department of Neurological Surgery, School of Medicine, University of California, 94143, San Francisco, CA aut Fobair Patricia Department of Radiation Oncology, Division of Radiation Therapy, Stanford University Medical Center, 94305, Palo Alto, CA, USA aut Prados Michael Neuro-Oncology Service, Brain Tumor Research Center, Department of Neurological Surgery, School of Medicine, University of California, 94143, San Francisco, CA aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/3(1992-11-01), 243-253 0167-594X 14:3<243 1992 14 11060 https://doi.org/10.1007/BF00172600 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172600 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mackworth Norman Neuro-Oncology Service, Brain Tumor Research Center, Department of Neurological Surgery, School of Medicine, University of California, 94143, San Francisco, CA aut NATIONALLICENCE 700 1- Fobair Patricia Department of Radiation Oncology, Division of Radiation Therapy, Stanford University Medical Center, 94305, Palo Alto, CA, USA aut NATIONALLICENCE 700 1- Prados Michael Neuro-Oncology Service, Brain Tumor Research Center, Department of Neurological Surgery, School of Medicine, University of California, 94143, San Francisco, CA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/3(1992-11-01), 243-253 0167-594X 14:3<243 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer