caa a22 4500 469117060 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00172604 doi (NATIONALLICENCE)springer-10.1007/BF00172604 Meningeal hemangiopericytoma: defining the role for radiation therapy [Elektronische Daten] [Kenneth Bastin, Minesh Mehta] Summary: Meningeal hemangiopericytoma is a rare neoplasm arising from perivascular pericytes. Accounting for < 1% of all brain tumors, these neoplasms are characterized by a high local recurrence rate and metastatic potential. Meningeal hemangiopericytoma occur most frequently during the fifth decade of life, with an almost equal sex incidence. To evaluate and define the role for primary, postoperative, or palliative radiotherapy in meningeal hemangiopericytoma, data were gathered from our own tumor registry and compiled with an extensive analysis of published series and case reports. This analysis reveals a 90%, 9 year actuarial risk for local recurrence following surgical resection only. Interestingly, less than 33% of these recurrences were noted within the first five years, which may account for the false assumption that these tumors are highly curable with surgical resection only. Radiation therapy appears to reduce this local recurrence rate, prolonging disease-free and overall survival. Radiation responses are dose dependent, with > 50 Gray providing superior long-term disease-free survival. Meningeal hemangiopericytoma are characterized by a slow, but progressive radiographic response to ionizing radiation, not unlike other radiated, highly vascular brain lesions, such as arteriovenous malformations. A retrospective review of clinical demographics, sites of meningeal origin, radiographic and pathologic findings and the role of chemotherapy is also presented. Kluwer Academic Publishers, 1992 hemangiopericytoma nationallicence meningeal hemangiopericytoma nationallicence radiation oncology nationallicence brain neoplasms nationallicence Bastin Kenneth Department of Human Oncology, University of Wisconsin Hospital and Clinics, 53792, Madison, WI, USA aut Mehta Minesh Department of Human Oncology, University of Wisconsin Hospital and Clinics, 53792, Madison, WI, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/3(1992-11-01), 277-287 0167-594X 14:3<277 1992 14 11060 https://doi.org/10.1007/BF00172604 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172604 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bastin Kenneth Department of Human Oncology, University of Wisconsin Hospital and Clinics, 53792, Madison, WI, USA aut NATIONALLICENCE 700 1- Mehta Minesh Department of Human Oncology, University of Wisconsin Hospital and Clinics, 53792, Madison, WI, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/3(1992-11-01), 277-287 0167-594X 14:3<277 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer