caa a22 4500 469117079 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00177620 doi (NATIONALLICENCE)springer-10.1007/BF00177620 Preventive effects of interleukin 1 β for ACNU-induced myelosuppression in malignant brain tumors: the experimental and preliminary clinical studies [Elektronische Daten] [Satoshi Tanaka, Sadaharu Tabuchi, Kenji Watanabe, Haruo Takigawa, Keiichi Akatsuka, Hideharu Numata, Yasuo Hokama, Tomokatsu Hori] Summary: The effect of recombinant human interleukin 1 β (rHuIL-1 β) on myelosuppression induced by 3-[(4-amino-2-methyl-5-pyrimidynyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU) was studied. In in vivo study using BALB/c mice, pretreatment with 1 µ g/mouse of rHuIL-1 β as a single intraperitoneal (i.p.) injection had a significant preventive effect on thrombocytopenia as well as granulocytopenia induced by ACNU at an intravenous dose of 60 mg/kg. Facilitated recovery by rHuIL-1 β administered seven days after injection of high-dose ACNU was also observed. Experimental combination immunochemotherapy with high-dose ACNU and rHuIL-1 β was performed in nude mice inoculated with human glioblastoma subcutaneously. The elongation of the survival time of the tumor bearing nude mice was also observed in combined use of high dose ACNU with rHuIL-1 β. Seven patients with malignant brain tumors received intravenous 2.5-3 mg/kg ACNU. All patients were subcutaneously injected with 2 × 104-U or more rHuIL-1 β twice a week or daily. The mean nadir of leukocyte, granulocyte, and thrombocyte counts of the 7 patients received 2.5-3 mg/kg ACNU were significantly higher than in matched historical controls. In combination with rHuIL-1 β, it may be possible to use chemotherapeutic agents at a relatively high dose. Kluwer Academic Publishers, 1992 interleukin 1 nationallicence malignant brain tumor nationallicence myelosuppression nationallicence ACNU nationallicence chemotherapy nationallicence Tanaka Satoshi Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut Tabuchi Sadaharu Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut Watanabe Kenji Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut Takigawa Haruo Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut Akatsuka Keiichi Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut Numata Hideharu Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut Hokama Yasuo Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut Hori Tomokatsu Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/2(1992-10-01), 159-168 0167-594X 14:2<159 1992 14 11060 https://doi.org/10.1007/BF00177620 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177620 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tanaka Satoshi Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Tabuchi Sadaharu Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Watanabe Kenji Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Takigawa Haruo Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Akatsuka Keiichi Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Numata Hideharu Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Hokama Yasuo Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Hori Tomokatsu Division of Neurosurgery, Institute of Neurological Sciences, School of Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/2(1992-10-01), 159-168 0167-594X 14:2<159 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer