caa a22 4500 469117087 CHVBK 20180323133128.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00177618 doi (NATIONALLICENCE)springer-10.1007/BF00177618 A case of treatment-related leukoencephalpathy: sequential MRI, CT and PET findings [Elektronische Daten] [Shin-ichi Miyatake, Haruhiko Kikuchi, Yoshifumi Oda, Masatsune Ishikawa, Masahiro Kojima, Keiko Matsubayashi, Jun Minamikawa, Sen Yamagata, Reinin Asato] Summary: A case of treatment-related leukoencephalopathy is presented. A patient with medulloblastoma was postoperatively treated with craniospinal axis irradiation. One month after irradiation, weekly intrathecal administration of methotrexate was performed 4 times to treat cerebrospinal fluid dissemination of the tumor. Two months after the initiation of intrathecal chemotherapy, the patient became somnolent and developed decerebrate posturing. Magnetic resonance imaging showed diffuse leukoencephalopathy. Positron emission tomography revealed a diffuse decrease in glucose uptake in the deep white matter. Auditory evoked potential also showed diffuse abnormalities, not only in the cerebrum, but also in the brain stem. High dose intravenous leucovorin rescue was attempted without any neurologic improvement. Kluwer Academic Publishers, 1992 CT nationallicence irradiation nationallicence leukoencephalopathy nationallicence methotrexate nationallicence MRI nationallicence PET nationallicence Miyatake Shin-ichi Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut Kikuchi Haruhiko Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut Oda Yoshifumi Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut Ishikawa Masatsune Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut Kojima Masahiro Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut Matsubayashi Keiko Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut Minamikawa Jun Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut Yamagata Sen Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut Asato Reinin Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/2(1992-10-01), 143-149 0167-594X 14:2<143 1992 14 11060 https://doi.org/10.1007/BF00177618 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177618 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miyatake Shin-ichi Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Kikuchi Haruhiko Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Oda Yoshifumi Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Ishikawa Masatsune Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Kojima Masahiro Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Matsubayashi Keiko Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Minamikawa Jun Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Yamagata Sen Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Asato Reinin Departments of Neurosurgery and Nuclear Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/2(1992-10-01), 143-149 0167-594X 14:2<143 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer