caa a22 4500 469117095 CHVBK 20180323133128.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00177622 doi (NATIONALLICENCE)springer-10.1007/BF00177622 In vivo CT measurement of blood-brain transfer constant of iopamidol in human brain tumors [Elektronische Daten] [W.T. Ivan Yeung, Ting-Yim Lee, Rolando Del Maestro, Roman Kozak, Thomas Brown] Summary: We have developed an in vivo method of measuring the blood-brain transfer constant (K) of iopamidol and the cerebral plasma volume (Vp) in brain tumors using a clinical X-ray CT scanner. In patient studies, Isovue 300 (iopamidol) was injected at a dosage of 1 ml/kg patient body weight. Serial CT scans of the tumor site and arterial blood samples from a radial artery were taken up to 48 min after injection. The leakage of iopamidol into the brain through the blood-brain barrier was modelled as an exchange process between two compartments, the intravascular plasma space and the tissue interstitial space. Using this model and the concentration measurements in blood plasma and tissue, quantitative estimates of K and Vp in brain tumors were obtained. In addition, distribution of the estimated values of K and Vp in tumors were displayed as false colour functional images overlaid on the conventional CT scan. In a study of twelve patients with anaplastic astrocytoma (n = 3), glioblastoma multiforme (n = 4) or metastases (n = 5) the mean K and VP values in tumor were found to be 0.0273 ± 0.0060 ml/min/g and 0.068 ± 0.11 ml/g respectively. These values were significantly higher than those in grey or white matter in the contralateral ‘normal' hemisphere (p < 0.05). The functional images showed variations in K and Vp within the tumor which were difficult to perceive in the original contrast enhanced CT scans. Kluwer Academic Publishers, 1992 brain tumors nationallicence blood-brain barrier nationallicence blood-brain transfer constant nationallicence x-ray CT nationallicence iopamidol nationallicence functional images nationallicence Ivan Yeung W.T. Department of Diagnostic Radiology, St. Joseph's Health Centre and University of Western Ontario, N6A 4G5, London, Ontario, Canada aut Lee Ting-Yim Department of Diagnostic Radiology, St. Joseph's Health Centre and University of Western Ontario, N6A 4G5, London, Ontario, Canada aut Del Maestro Rolando Brain Research Laboratory, Clinical Research Unit, Department of Clinical Neurological Sciences, University of Western Ontario, N6A 4G5, London, Ontario, Canada aut Kozak Roman Department of Diagnostic Radiology, St. Joseph's Health Centre and University of Western Ontario, N6A 4G5, London, Ontario, Canada aut Brown Thomas Department of Diagnostic Radiology, St. Joseph's Health Centre and University of Western Ontario, N6A 4G5, London, Ontario, Canada aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/2(1992-10-01), 177-187 0167-594X 14:2<177 1992 14 11060 https://doi.org/10.1007/BF00177622 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177622 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ivan Yeung W.T. Department of Diagnostic Radiology, St. Joseph's Health Centre and University of Western Ontario, N6A 4G5, London, Ontario, Canada aut NATIONALLICENCE 700 1- Lee Ting-Yim Department of Diagnostic Radiology, St. Joseph's Health Centre and University of Western Ontario, N6A 4G5, London, Ontario, Canada aut NATIONALLICENCE 700 1- Del Maestro Rolando Brain Research Laboratory, Clinical Research Unit, Department of Clinical Neurological Sciences, University of Western Ontario, N6A 4G5, London, Ontario, Canada aut NATIONALLICENCE 700 1- Kozak Roman Department of Diagnostic Radiology, St. Joseph's Health Centre and University of Western Ontario, N6A 4G5, London, Ontario, Canada aut NATIONALLICENCE 700 1- Brown Thomas Department of Diagnostic Radiology, St. Joseph's Health Centre and University of Western Ontario, N6A 4G5, London, Ontario, Canada aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/2(1992-10-01), 177-187 0167-594X 14:2<177 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer