caa a22 4500 469117109 CHVBK 20180323133128.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00177617 doi (NATIONALLICENCE)springer-10.1007/BF00177617 Extraneural metastases in ependymoma [Elektronische Daten] [Herbert Newton, John Henson, Russel Walker] Summary: Ependymomas, glial neoplasms usually arising in the posterior fossa or spinal cord, rarely metastasize outside the central nervous system. We have reviewed all 81 ependymomas evaluated at MSKCC between 1956-1989. Five (6.2%) had extraneural metastases (ENM). The primary tumor was in spinal cord in 3 patients and the cerebral hemisphere in 2. Two tumors were histologically anaplastic; 3 were histologically benign. The 5 patients were 3, 3, 3.5, 16 and 37 years old. Time from initial diagnosis to development of ENM was 0, 15, 35, 40, and 288 months. At the time of ENM the primary tumor was progressing in 4/5 patients. Prior therapy had included resection plus radiation therapy (RT) (1), RT plus chemotherapy (1), resection plus RT plus chemotherapy (2). One patient had not received prior therapy because ENM were present at diagnosis. The sites of ENM included lung and thoracic lymph nodes (2), pleura and peritoneum (2), and liver (1). Both patients with peritoneal ENM had had ventriculoperitoneal shunts. ENM did not correlate with histologic grade, age, or degree of surgical resection. When patients with ependymoma develop signs or symptoms of systemic disease such as abdominal pain, cough, or adenopathy, ENM should be considered. Kluwer Academic Publishers, 1992 ependymoma nationallicence metastases nationallicence extraneural nationallicence Newton Herbert Department of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, NY, USA aut Henson John Department of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, NY, USA aut Walker Russel Department of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, NY, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/2(1992-10-01), 135-142 0167-594X 14:2<135 1992 14 11060 https://doi.org/10.1007/BF00177617 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177617 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Newton Herbert Department of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, NY, USA aut NATIONALLICENCE 700 1- Henson John Department of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, NY, USA aut NATIONALLICENCE 700 1- Walker Russel Department of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, NY, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/2(1992-10-01), 135-142 0167-594X 14:2<135 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer