caa a22 4500 469117176 CHVBK 20180323133128.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00177612 doi (NATIONALLICENCE)springer-10.1007/BF00177612 p53 gene mutations in primary lung tumors are conserved in brain metastases [Elektronische Daten] [Uwe Schlegel, Myrna Rosenfeld, Matthias Volkenandt, Marc Rosenblum, Josep Dalmau, Henry Furneaux] The p53 product is frequently mutated in human tumors. Both acquired and inherited mutations have been described. These mutations transform p53 from a growth suppressor gene to a transforming oncogene. We examined tissue from 6 patients with primary lung carcinoma and the corresponding brain metastases for the presence of p53 mutations by immunohistochemistry. We then confirmed and characterized the mutations by single strand conformation analysis and by direct sequence analysis. All 6 patients had primary and metastatic tumor expressing a mutant p53. The mutations were all G-T transversions and mapped to exons 5, 6, 7, and 8. The mutations in the primary tumors were precisely conserved in the brain metastases. Kluwer Academic Publishers, 1992 p53 nationallicence lung tumors nationallicence brain metastasis nationallicence Schlegel Uwe From the Laboratory of Molecular Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, USA aut Rosenfeld Myrna From the Laboratory of Molecular Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, USA aut Volkenandt Matthias Laboratory of Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center, USA aut Rosenblum Marc Department of Pathology, Memorial Sloan-Kettering Cancer Center, USA aut Dalmau Josep From the Laboratory of Molecular Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, USA aut Furneaux Henry From the Laboratory of Molecular Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 14/2(1992-10-01), 93-100 0167-594X 14:2<93 1992 14 11060 https://doi.org/10.1007/BF00177612 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177612 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schlegel Uwe From the Laboratory of Molecular Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, USA aut NATIONALLICENCE 700 1- Rosenfeld Myrna From the Laboratory of Molecular Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, USA aut NATIONALLICENCE 700 1- Volkenandt Matthias Laboratory of Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center, USA aut NATIONALLICENCE 700 1- Rosenblum Marc Department of Pathology, Memorial Sloan-Kettering Cancer Center, USA aut NATIONALLICENCE 700 1- Dalmau Josep From the Laboratory of Molecular Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, USA aut NATIONALLICENCE 700 1- Furneaux Henry From the Laboratory of Molecular Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 14/2(1992-10-01), 93-100 0167-594X 14:2<93 1992 14 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer