caa a22 4500 469118474 CHVBK 20180323133131.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF02245884 doi (NATIONALLICENCE)springer-10.1007/BF02245884 Strain differences in sensitivity to the hypothermic effects of benzodiazepine receptor ligands in mice [Elektronische Daten] [Helen Jackson, David Nutt] The hypothermic effects of intraperitoneal (IP) administration of the full benzodiazepine agonist lop razolam (1, 10 mg/kg); the partial agonist Ro 17-1812 (1, 10 mg/kg); the benzodiazepine receptor antagonist flumazenil (10, 20 mg/kg); the benzodiazepine inverse agonists Ro 15-4513 (1, 3, 10 mg/kg) and Ro 19-4603 (0.03, 0.1, 0.3 mg/kg) and theβ-carboline inverse agonists FG 7142 (10, 30 mg/kg) and DMCM (1, 3, 10 mg/kg) were investigated in three strains of mice. TO mice were less sensitive than CBA/cA and DBA/2 mice, since only loprazolam and the partial and fullβ-carboline inverse agonists FG 7142 and DMCM lowered body temperature in these animals. CBA/cA mice were particularly sensitive to the hypothermic effects of loprazolam and Ro 17-1812, and also responded to theβ-carboline but not the benzo diazepine inverse agonists. In contrast, DBA/2 mice responded with moderate hypothermia to loprazolam, Ro 17-1812, and to the partial inverse agonist Ro 15-4513, and exhibited marked hypothermia in response to the more efficacious benzodiazepine inverse agonist Ro 19-4603 and to FG 7142 and DMCM. Flumazenil did not alter body temperature. DBA/2 mice were also more sensitive to the convulsant activity of inverse agonists than TO mice. CBA/cA mice exhibited enhanced sensitivity to the convulsant, but not the hypothermic, effects of Ro 19-4603, showing dissociation of these responses. The mechanisms underlying the genetic differences in sensitivity of mice to the hypothermic and convulsant action of the different ligands are unknown and warrant further investigation. Springer-Verlag, 1992 Benzodiazepine receptors nationallicence Full and partial agonists nationallicence Inverse agonists nationallicence Body temperature nationallicence Seizures nationallicence Strain differences in mice nationallicence Jackson Helen Reckitt & Colman Psychopharmacology Unit, Department of Pharmacology, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK aut Nutt David Reckitt & Colman Psychopharmacology Unit, Department of Pharmacology, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK aut Psychopharmacology Springer-Verlag 109/3(1992-11-01), 365-368 0033-3158 109:3<365 1992 109 213 https://doi.org/10.1007/BF02245884 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245884 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jackson Helen Reckitt & Colman Psychopharmacology Unit, Department of Pharmacology, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK aut NATIONALLICENCE 700 1- Nutt David Reckitt & Colman Psychopharmacology Unit, Department of Pharmacology, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/3(1992-11-01), 365-368 0033-3158 109:3<365 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer