caa a22 4500 469118490 CHVBK 20180323133131.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF02245881 doi (NATIONALLICENCE)springer-10.1007/BF02245881 N -methyl- d -aspartate lesions of the lateral hypothalamus do not reduce amphetamine or fenfluramine anorexia but enhance the acquisition of eating in response to tail pinch in the rat [Elektronische Daten] [Judith Clark, Andrew Clark, Philip Winn] These experiments examine the acquisition of tail pinch-induced eating and responses to the anorectic agentsd-amphetamine andd,l-fenfluramine by rats bearingN-methyl-d-aspartate (NMDA) lesions of the lateral hypothalamus. Lesioned rats lost weight following surgery but had no significant eating or drinking difficulties in the home cage (Clark et al. 1990). The acquisition of eating in response to tail pinch was enhanced in lateral hypothalamic-lesioned rats: they ate on earlier test sessions than controls and less pressure was required to elicit eating. Home cage food intake over the period when tail pinch was being examined was not affected by the lateral hypothalamic lesions. There were no significant differences between lateral hypothalamic-lesioned and control rats in terms of their anorectic responses to eitherd-amphetamine ord,l-fenfluramine, though the lesioned rats had a lower baseline intake. These data suggest that the lateral hypothalamus is not an important site for the mediation of amphetamine or fenfluramine anorexia but is involved in the acquisition of tail pinch-induced eating. The disinhibition of responding to tail pinch by lateral hypothalamic lesions is discussed in terms of the possible role the lateral hypothalamus plays in regulating cortical activity. The role of the medial hypothalamus and nonhypothalamic systems in the response to anorectic drugs and tail pinch is discussed. Springer-Verlag, 1992 Lateral hypothalamus nationallicence Eating nationallicence Excitotoxic lesion nationallicence Amphetamine nationallicence Fenfluramine nationallicence Anorexia nationallicence Tail pinch nationallicence Clark Judith Department of Psychology, University of St. Andrews, KY16 9JU, St. Andrews, Fife, UK aut Clark Andrew Department of Psychology, University of St. Andrews, KY16 9JU, St. Andrews, Fife, UK aut Winn Philip Department of Psychology, University of St. Andrews, KY16 9JU, St. Andrews, Fife, UK aut Psychopharmacology Springer-Verlag 109/3(1992-11-01), 331-337 0033-3158 109:3<331 1992 109 213 https://doi.org/10.1007/BF02245881 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245881 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Clark Judith Department of Psychology, University of St. Andrews, KY16 9JU, St. Andrews, Fife, UK aut NATIONALLICENCE 700 1- Clark Andrew Department of Psychology, University of St. Andrews, KY16 9JU, St. Andrews, Fife, UK aut NATIONALLICENCE 700 1- Winn Philip Department of Psychology, University of St. Andrews, KY16 9JU, St. Andrews, Fife, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/3(1992-11-01), 331-337 0033-3158 109:3<331 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer