caa a22 4500 469118504 CHVBK 20180323133131.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF02245888 doi (NATIONALLICENCE)springer-10.1007/BF02245888 Anxiogenic drugs beta-CCE and FG 7142 increase extracellular dopamine levels in nucleus accumbens [Elektronische Daten] [L. McCullough, J. Salamone] Two experiments were conducted to study the effects of anxiogenic drugs on dopamine release and metabolism in nucleus accumbens. Microdialysis probes were implanted into the nucleus accumbens, and rats were tested the day after implantation. In the first experiment, groups of rats received injections of saline, 1.25 or 2.5 mg/kg beta-CCE. In the second experiment, groups of rats received injections of saline, 10.0, 20.0 or 30.0 mg/kg FG-7142. Both drugs produced significant increases in dopamine release and metabolism in nucleus accumbens. Neither drug had significant effects on locomotor activity. These experimeriments indicate that exposure to anxiogenic drugs increases accumbens dopamine activity, an effect that is consistent with other studies showing that the mesolimbic dopamine system is responsive to stressful stimuli. In addition, these results demonstrate that drug-induced increases in accumbens dopamine release are not unique to drugs of abuse. Springer-Verlag, 1992 Anxiogenic drugs nationallicence Beta-CCE nationallicence FG 7142 nationallicence Dopamine nationallicence Nucleus accumbens nationallicence Stress nationallicence Microdialysis nationallicence McCullough L. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut Salamone J. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut Psychopharmacology Springer-Verlag 109/3(1992-11-01), 379-382 0033-3158 109:3<379 1992 109 213 https://doi.org/10.1007/BF02245888 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245888 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McCullough L. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut NATIONALLICENCE 700 1- Salamone J. Department of Psychology, University of Connecticut, 06269-1020, Storrs, CT, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/3(1992-11-01), 379-382 0033-3158 109:3<379 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer