caa a22 4500 469118512 CHVBK 20180323133131.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF02245886 doi (NATIONALLICENCE)springer-10.1007/BF02245886 Effects of intra-hippocampal scopolamine injections in a repeated spatial acquisition task in the rat [Elektronische Daten] [Arjan Blokland, Wiel Honig, Wijnand Raaijmakers] The involvement of hippocampal cholinergic synapses in spatial discrimination learning was evaluated by locally administering scopolamine into the hippocampus. Sixteen 16-month-old male Lewis rats received bilaterally implanted cannulae aimed at the dorsal part of the hippocampus. The rats were trained on a repeated acquisition test in the Morris water-escape task. In this procedure the invisible platform is randomly moved from day to day to one of four possible locations. Thus, the rat has to learn to localize the platform from day to day. On each day the rats received four pairs of trials. Scopolamine injections (35 µg in 1 μl per hippocampus) were given to one group (n=8) on days 5 and 7. On days 6 and 8 all rats received saline injections. Place learning was retarded in the scopolamine-treated rats during the first swims of pairs of trials. During second swims the scopolamine-treated rats showed a general performance deficit, indicating that first and second swims were differentially affected. The data support the hypothesis that cholinergic neurotransmission in the dorsal hippocampus is involved in spatial learning processes. Springer-Verlag, 1992 Cholinergic system nationallicence Scopolamine nationallicence Hippocampus nationallicence Spatial discrimination nationallicence Learning nationallicence Rat nationallicence Blokland Arjan Department of Neuropsychology and Psychobiology, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut Honig Wiel Department of Neuropsychology and Psychobiology, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut Raaijmakers Wijnand Department of Neuropsychology and Psychobiology, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut Psychopharmacology Springer-Verlag 109/3(1992-11-01), 373-376 0033-3158 109:3<373 1992 109 213 https://doi.org/10.1007/BF02245886 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245886 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blokland Arjan Department of Neuropsychology and Psychobiology, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Honig Wiel Department of Neuropsychology and Psychobiology, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Raaijmakers Wijnand Department of Neuropsychology and Psychobiology, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/3(1992-11-01), 373-376 0033-3158 109:3<373 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer