caa a22 4500 469118520 CHVBK 20180323133131.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF02245880 doi (NATIONALLICENCE)springer-10.1007/BF02245880 Effects of physostigmine and scopolamine on rats' performances in object-recognition and radial-maze tests [Elektronische Daten] [Abdelkader Ennaceur, Kamel Meliani] The effects of physostigmine and scopolamine were evaluated on working memory of rats in object recognition and radial-maze tests. Three doses of physostigmine hemi-sulfate (Phys: 0.05, 0.10 and 0.20 mg/kg), five doses of scopolamine hydrobromide (Scop: 0.125, 0.25, 0.5, 1.0 and 2.0 mg/kg), and one dose of scopolamine methylbromide (Mscop: 2.0 mg/kg) were used. In object recognition test, rats were submitted to three or four intertrial delay conditions (1-min, 15-min and either 60-min or 24-h). The higher doses of Scop (1.0 and 2.0 mg/kg) in 1-min and 15-min delay and of Phys (0.20 mg/kg) in 1-min delay impaired discrimination between new and familiar objects. Mscop impaired discrimination between objects in 60-min but not in 1-min and 15-min delay. This effect may be state dependent. Radial-maze learning was impaired by the lower doses of scopolamine (0.25 and 0.50 mg/kg) which had no effect in object recognition test. These results show that in our conditions, object recognition is less sensitive than radial-maze test to cholinergic drugs. Springer-Verlag, 1992 Physostigmine nationallicence Scopolamine nationallicence Object-recognition nationallicence Radial-maze nationallicence Working-memory nationallicence State-dependence nationallicence Rats nationallicence Ennaceur Abdelkader Laboratoire de Psychophysiologie, Université Paris VII, 2 Place Jussieu, F-75251, Paris Cedex 05, France aut Meliani Kamel Institut National de la Planification et des Statistiques, Université Ben Aknoun, Algiers, Algeria aut Psychopharmacology Springer-Verlag 109/3(1992-11-01), 321-330 0033-3158 109:3<321 1992 109 213 https://doi.org/10.1007/BF02245880 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245880 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ennaceur Abdelkader Laboratoire de Psychophysiologie, Université Paris VII, 2 Place Jussieu, F-75251, Paris Cedex 05, France aut NATIONALLICENCE 700 1- Meliani Kamel Institut National de la Planification et des Statistiques, Université Ben Aknoun, Algiers, Algeria aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/3(1992-11-01), 321-330 0033-3158 109:3<321 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer