caa a22 4500 469118539 CHVBK 20180323133131.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF02245885 doi (NATIONALLICENCE)springer-10.1007/BF02245885 Antidepressant-like effect of neurotensin administered in the ventral tegmental area in the forced swimming test [Elektronische Daten] [L. Cervo, C. Rossi, E. Tatarczynska, R. Samanin] Locomotor activity and behaviour in the forced swimming test were examined in rats which had received neurotensin (0.5-5.0 µg) in the ventral tegmental area. Doses of 5 µg neurotensin but not lower increased the locomotor activity for at least 2 h. At 0.5 and 1.0 µg neurotensin significantly increased the time the animals spent in struggling with no changes in general motor activity (swimming). The effect of 1.0 µg neurotensin on struggling was completely antagonized by 0.5 µg (−)-sulpiride administered in the posterior nucleus accumbens. The results suggest that activation of the mesolimbic dopamine system through administration of neurotensin in the ventral tegmental area produces antidepressant-like effects. The significance of these findings for a role of endogenous neurotensin in depression remains to be clarified. Springer-Verlag, 1992 Neurotensin nationallicence Dopamine nationallicence Mesolimbic system nationallicence Antidepressant activity nationallicence Rat nationallicence Cervo L. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Rossi C. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Tatarczynska E. Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland aut Samanin R. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Psychopharmacology Springer-Verlag 109/3(1992-11-01), 369-372 0033-3158 109:3<369 1992 109 213 https://doi.org/10.1007/BF02245885 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245885 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cervo L. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Rossi C. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Tatarczynska E. Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland aut NATIONALLICENCE 700 1- Samanin R. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/3(1992-11-01), 369-372 0033-3158 109:3<369 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer