caa a22 4500 469118555 CHVBK 20180323133131.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF02245873 doi (NATIONALLICENCE)springer-10.1007/BF02245873 Decreased sensory responsiveness of noradrenergic neurons in the rat locus coeruleus following phencyclidine or dizocilpine (MK-801): role of NMDA antagonism [Elektronische Daten] [Sumio Murase, Magnus NIsell, Johan Grenhoff, Torgny Svensson] The effects of the schizophrenomimetic compound phencyclidine (PCP) on baseline activity and sensory-evoked responses of noradrenergic locus coeruleus neurons were studied with extracellular single-cell recording techniques in the chloral hydrate-anaesthetized male albino rat. PCP dose-dependently decreased firing rate, induced a more regular firing pattern of the neurons, and decreased neuronal responses to a peripheral sensory stimulus (electrical stimulation of the hindpaw). These effects of PCP were significantly decreased by pretreatment with reserpine or yohimbine, indicating that the effects of PCP were largely indirect and mediated through noradrenaline, i.e. by inhibition of its re-uptake, resulting in stimulation of α2 autoreceptors. The effects of PCP were, however, mimicked by dizocilpine (MK-801), a selective non-competitive antagonist at excitatory amino acid receptors of the N-methyl-d-aspartate (NMDA) subtype, suggesting a role also for NMDA receptors in the suppression of sensory responsiveness of locus coeruleus neurons by PCP. In view of the purported physiological role of the locus coeruleus, this effect of PCP may well contribute to the psychotomimetic properties of the drug. Springer-Verlag, 1992 Alpha-2 adrenoceptors nationallicence Dissociative anaesthesia nationallicence Excitatory amino acids nationallicence PCP psychosis nationallicence Reserpine nationallicence Yohimbine nationallicence Murase Sumio Department of Pharmacology, Karolinska Institutet, P.O. Box 60400, S-104 01, Stockholm, Sweden aut NIsell Magnus Department of Pharmacology, Karolinska Institutet, P.O. Box 60400, S-104 01, Stockholm, Sweden aut Grenhoff Johan Department of Pharmacology, Karolinska Institutet, P.O. Box 60400, S-104 01, Stockholm, Sweden aut Svensson Torgny Department of Pharmacology, Karolinska Institutet, P.O. Box 60400, S-104 01, Stockholm, Sweden aut Psychopharmacology Springer-Verlag 109/3(1992-11-01), 271-276 0033-3158 109:3<271 1992 109 213 https://doi.org/10.1007/BF02245873 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245873 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Murase Sumio Department of Pharmacology, Karolinska Institutet, P.O. Box 60400, S-104 01, Stockholm, Sweden aut NATIONALLICENCE 700 1- NIsell Magnus Department of Pharmacology, Karolinska Institutet, P.O. Box 60400, S-104 01, Stockholm, Sweden aut NATIONALLICENCE 700 1- Grenhoff Johan Department of Pharmacology, Karolinska Institutet, P.O. Box 60400, S-104 01, Stockholm, Sweden aut NATIONALLICENCE 700 1- Svensson Torgny Department of Pharmacology, Karolinska Institutet, P.O. Box 60400, S-104 01, Stockholm, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/3(1992-11-01), 271-276 0033-3158 109:3<271 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer