caa a22 4500 469118601 CHVBK 20180323133131.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF02245872 doi (NATIONALLICENCE)springer-10.1007/BF02245872 Effects of ketanserin and mianserin on delayed neuronal death induced by cerebral ischemia in Mongolian gerbils [Elektronische Daten] [Yasuko Karasawa, Hiroaki Araki, Susumu Otomo] We examined whether ketanserin and mianserin, drugs with 5-HT2 receptor antagonistic effects, would have protective effects in Mongolian gerbils on delayed neuronal death induced by cerebral ischemia. When training and test sessions in the passive avoidance task were carried out 6 and 7 days after 3 min of ischemia, passive avoidance impairment was apparent. Destruction and disappearance was apparent in the hippocampal CA1 neurons at 7 days after the induced ischemia. Administration of ketanserin (5-20 mg/kg) and mianserin (5-20 mg/kg) led to better passive avoidance and prevented the delayed neuronal death induced by the ischemia. These effects of ketanserin and mianserin were not inhibited by treatment with the cholinergic blocker scopolamine (5 mg/kg). Thus, ketanserin and mianserin have a protective effect on delayed neuronal death in gerbils and the effects of these drugs are not mediated by serotonergic and cholinergic systems. Springer-Verlag, 1992 Cerebral ischemia nationallicence Delayed neuronal death nationallicence Ketanserin and mianserin nationallicence Mongolian gerbil nationallicence Karasawa Yasuko Department of Pharmacology, Research Center, Taisho Pharmaceutical, Yoshino-cho 1-403, Ohmiya, 330, Saitama, Japan aut Araki Hiroaki Department of Pharmacology, Research Center, Taisho Pharmaceutical, Yoshino-cho 1-403, Ohmiya, 330, Saitama, Japan aut Otomo Susumu Department of Pharmacology, Research Center, Taisho Pharmaceutical, Yoshino-cho 1-403, Ohmiya, 330, Saitama, Japan aut Psychopharmacology Springer-Verlag 109/3(1992-11-01), 264-270 0033-3158 109:3<264 1992 109 213 https://doi.org/10.1007/BF02245872 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245872 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karasawa Yasuko Department of Pharmacology, Research Center, Taisho Pharmaceutical, Yoshino-cho 1-403, Ohmiya, 330, Saitama, Japan aut NATIONALLICENCE 700 1- Araki Hiroaki Department of Pharmacology, Research Center, Taisho Pharmaceutical, Yoshino-cho 1-403, Ohmiya, 330, Saitama, Japan aut NATIONALLICENCE 700 1- Otomo Susumu Department of Pharmacology, Research Center, Taisho Pharmaceutical, Yoshino-cho 1-403, Ohmiya, 330, Saitama, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/3(1992-11-01), 264-270 0033-3158 109:3<264 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer