caa a22 4500 469118636 CHVBK 20180323133131.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247717 doi (NATIONALLICENCE)springer-10.1007/BF02247717 Differential effects of serotonergic and catecholaminergic drugs on ingestive behavior [Elektronische Daten] [Karen Asin, John Davis, Lisa Bednarz] The serotonergic agonists fenfluramine and fluoxetine and the catecholaminergic agonists amphetamine and phenylpropanolamine are well known to cause a reduction in intake in rats. In the studies reported here we investigated the effects of these drugs on the microstructure of licking behavior of the rat ingesting 0.4 M sucrose. The purpose was to examine the similarities in the behavioral effects within and between these two classes of anorectic agents. The serotonergic agonists fenfluramine and fluoxetine caused a reduction in intake primarily by reducing the size of bursts and clusters of licking within the test meal without affecting the duration of the meal, suggesting a reduction in the palatability of the test solution. The catecholamine agonists amphetamine and phenylpropanolamine reduced intake primarily by reducing the number of bursts and clusters without affecting their size, suggesting a fractionation in the organization of the normal pattern of ingestion. The differences between the two serotonin and the two catecholamine agonists on the microstructure of the licking behavior suggest a different effect of the two neurotransmitters on the motor system that controls ingestive behavior. The similarities between the two different agonists within each class suggests a common neurotransmitter mechanism responsible for these two different effects on the behavior of the animals. Springer-Verlag, 1992 Anorectics nationallicence Ingestion rate nationallicence Microstructure of ingestion nationallicence Food intake nationallicence Sugars nationallicence Carbohydrate nationallicence Amphetamine nationallicence Fenfluramine nationallicence Fluoxetine nationallicence Phenylpropanolamine nationallicence Serotonin nationallicence Norepinephrine nationallicence Asin Karen Abbott Laboratories, Neuroscience Research Division, Pharmaceutical Discovery, Department 47H, Building AP10, 60064, Abbott Park, IL, USA aut Davis John Department of Psychology, University of Illinois, Chicago, 1009 Behavioral Science Building, 60680, Chicago, IL, USA aut Bednarz Lisa Abbott Laboratories, Neuroscience Research Division, Pharmaceutical Discovery, Department 47H, Building AP10, 60064, Abbott Park, IL, USA aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 415-421 0033-3158 109:4<415 1992 109 213 https://doi.org/10.1007/BF02247717 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247717 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Asin Karen Abbott Laboratories, Neuroscience Research Division, Pharmaceutical Discovery, Department 47H, Building AP10, 60064, Abbott Park, IL, USA aut NATIONALLICENCE 700 1- Davis John Department of Psychology, University of Illinois, Chicago, 1009 Behavioral Science Building, 60680, Chicago, IL, USA aut NATIONALLICENCE 700 1- Bednarz Lisa Abbott Laboratories, Neuroscience Research Division, Pharmaceutical Discovery, Department 47H, Building AP10, 60064, Abbott Park, IL, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 415-421 0033-3158 109:4<415 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer