caa a22 4500 469118652 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247714 doi (NATIONALLICENCE)springer-10.1007/BF02247714 Effects of anxiolytic and antidepressant drugs on long-lasting behavioural deficits resulting from one short stress experience in male rats [Elektronische Daten] [Hielke Van Dijken, Fred Tilders, Berend Olivier, Jan Mos] Exposure of male Wistar rats to one single session of ten inescapable footshocks induces changes in the behavioural responses to environmental stimuli as measured in the "noise test” 14 days later. Shocked (S) rats showed decreased locomotion and rearing during the first 3 min of exposure to a novel environment compared to control (C) rats. When the 85 dB background noise was switched off a marked immobility response emerged in S rats, concomitant with a further decrease in locomotion and rearing. In response to noise off, C rats showed hardly any immobility and a much smaller reduction in locomotion and rearing compared to S rats. These long-lasting changes in behaviour were not reversed by acute treatment with the antidepressants fluvoxamine (3.0-30.0 mg/kg) and desmethylimipramine (DMI, 2.5-10.0 mg/kg) injected IP 30 min before the noise test on day 14 following the shock session. Chronic treatment (day 1 to day 14) with flvoxamine or DMI did not reverse the behavioural deficits induced by shock exposure. Diazepam (0.6-5.0 mg/kg) administered acutely only reversed the effects of shock on locomotion during the first 3 min of the noise test. Chronic treatment with diazepam normalized the shock-induced decrease in locomotion and attenuated the rearing decrease during the first 3 min of the test, and partially restored shock-induced changes in behavioural response to switching off the noise. The most potent drug in this study was the 5-HT1A receptor agonist flesinoxan (0.3-3.0 mg/kg). Both acute and chronic drug treatment were equally effective in reversing the shock-induced locomotion deficits as well as the marked immobility response in S rats, although rearing was not reversed. However, flesinoxan also increased locomotion and reduced rearing in C rats, suggesting some nonspecific stimulating effects of flesinoxan. In conclusion, the footshock-induced long-lasting behavioural changes are sensitive to treatment with (putative) anxiolytic agents, whereas no beneficial effect of the antidepressant drugs was found. Springer-Verlag, 1992 Footshock nationallicence Stress nationallicence Behaviour nationallicence Diazepam nationallicence Flesinoxan nationallicence Fluvoxamine nationallicence Desmethylimipramine nationallicence Anxiety nationallicence Depression nationallicence Rat nationallicence Van Dijken Hielke Department of Pharmacology, Medical Faculty, Free University, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut Tilders Fred Department of Pharmacology, Medical Faculty, Free University, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut Olivier Berend CNS Pharmacology, Solvay Duphar B.V., P.O. Box 900, NL-1380 DA, Weesp, The Netherlands aut Mos Jan CNS Pharmacology, Solvay Duphar B.V., P.O. Box 900, NL-1380 DA, Weesp, The Netherlands aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 395-402 0033-3158 109:4<395 1992 109 213 https://doi.org/10.1007/BF02247714 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247714 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Van Dijken Hielke Department of Pharmacology, Medical Faculty, Free University, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Tilders Fred Department of Pharmacology, Medical Faculty, Free University, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Olivier Berend CNS Pharmacology, Solvay Duphar B.V., P.O. Box 900, NL-1380 DA, Weesp, The Netherlands aut NATIONALLICENCE 700 1- Mos Jan CNS Pharmacology, Solvay Duphar B.V., P.O. Box 900, NL-1380 DA, Weesp, The Netherlands aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 395-402 0033-3158 109:4<395 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer