caa a22 4500 469118679 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247730 doi (NATIONALLICENCE)springer-10.1007/BF02247730 Concentration of ondansetron in cerebrospinal fluid following oral dosing in volunteers [Elektronische Daten] [K. Simpson, P. Murphy, P. Colthup, P. Whelan] This study measured the concentrations of ondansetron in plasma and cerebrospinal fluid (CSF) in six volunteers after oral dosing to steady state. Ondansetron concentrations ranged from 39.5-147 ng ml−1 in plasma and from 2.6-15.4 ng ml−1 in CSF. There was good correlation between plasma and CSF concentrations (r=0.89,p=0.017). CSF concentrations were less than 15% of plasma concentrations in all cases, indicating that the rate of penetration of the blood brain barrier by ondansetron is low. Springer-Verlag, 1992 Ondansetron nationallicence Blood brain barrier nationallicence Cerebrospinal fluid nationallicence Simpson K. University Department of Anaesthesia, St. James's University Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Murphy P. University Department of Anaesthesia, St. James's University Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Colthup P. Glaxo Group Research Ltd, Park Road, SG12 ODP, Ware, Hertfordshire, UK aut Whelan P. Department of Urology, St. James's University Hospital, Beckett Street, LS9 7TF, Leeds, UK aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 497-498 0033-3158 109:4<497 1992 109 213 https://doi.org/10.1007/BF02247730 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247730 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Simpson K. University Department of Anaesthesia, St. James's University Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Murphy P. University Department of Anaesthesia, St. James's University Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 700 1- Colthup P. Glaxo Group Research Ltd, Park Road, SG12 ODP, Ware, Hertfordshire, UK aut NATIONALLICENCE 700 1- Whelan P. Department of Urology, St. James's University Hospital, Beckett Street, LS9 7TF, Leeds, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 497-498 0033-3158 109:4<497 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer