caa a22 4500 469118709 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247715 doi (NATIONALLICENCE)springer-10.1007/BF02247715 Differential antagonism of the effects of dopamine D1-receptor agonists on feeding behavior in the rat [Elektronische Daten] [Philip Terry, Jonathan Katz] A series of experiments was conducted to examine the effects of dopamine D1 receptor agonists on food intake in rats. In the first experiment, the D1 agonist SKF 38393 (3.0-30.0 mg/kg) dose-dependently suppressed feeding during a 40 min food-access period, both in food-deprived rats and in non-deprived rats fed a highly palatable diet. Non-deprived rats were more sensitive to these effects of SKF 38393. Using the limited-access, food-deprivation procedure, a comparison was made between the anorectic effects of three D1 agonists with differing intrinsic efficacies and receptor selectivities. Rank order of potencies for reducing food intake was SKF 82958 > SKF 77434 > SKF 38393 (ED50 values: 0.7, 3.6 and 15.7 mg/kg, respectively). Dose-related, surmountable antagonism by the D1 antagonist SCH 23390 (0.01 and 0.03 mg/kg) was only obtained with SKF 82958 (0.1-10.0 mg/kg). In contrast to the other compounds, the effects of SKF 38393 were not appreciably altered by the D1 antagonist. The effects of SKF 82958 were also antagonized by the D2 receptor antagonist spiperone (0.05 and 0.1 mg/kg), although not in a dose-dependent manner. The present results support a role for D1 receptors in central feeding mechanisms. They also suggest that the effects of SKF 38393 on feeding may not be mediated exclusively by the D1 receptor and, further, that SKF 38393 may not serve well in behavioral studies as a prototypical D1 agonist. The results also demonstrate the need for comparisons among several compounds in studies of D1 mediated behavioral effects. Springer-Verlag, 1992 Dopamine nationallicence D1 nationallicence D2 nationallicence SKF 38393 nationallicence SKF 77434 nationallicence SKF 82958 nationallicence SCH 23390 nationallicence Spiperone nationallicence Feeding nationallicence Behavior nationallicence Rat nationallicence Terry Philip Psychobiology Section, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut Katz Jonathan Psychobiology Section, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 403-409 0033-3158 109:4<403 1992 109 213 https://doi.org/10.1007/BF02247715 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247715 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Terry Philip Psychobiology Section, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Katz Jonathan Psychobiology Section, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 403-409 0033-3158 109:4<403 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer