caa a22 4500 469118717 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247728 doi (NATIONALLICENCE)springer-10.1007/BF02247728 Performance of baboons under a repeated acquisition procedure during chronic oral exposure to atenolol and propranolol [Elektronische Daten] [Jaylan Turkkan, Robert Hienz] Repeated acquisition behavioral performances of normotensive and renovascular hypertensive baboons were tested before, during, and following chronic oral dosing with theβ-adrenergic antagonists atenolol HC1 (2.6 mg/kg/day PO), andd,l propranolol HC1 (6.8 mg/kg twice daily PO) in separate studies. Each study administered active drug for 21 consecutive days preceded and followed by 14-day baseline and recovery periods, respectively. Animals pressed five keys in sequence for food reinforcement during daily experimental sessions which consisted of alternating acquisition (new sequence learning) and performance (previously learned) task components. Atenolol increased response latencies during acquisition in comparison to performance components, and during early portions of sessions. Propranolol also increased response latencies during acquisition components in early periods of sessions, but fewer dependent measures were affected, and the magnitude of increases in response latencies was smaller (12%±5 SEM) as compared with atenolol (47%±13). Test doses of phencyclidine HC1 (PCP) increased latencies to the same degree as atenolol. PCP markedly reduced accuracy, while atenolol or propranolol did not. Blood pressures remained stable under atenolol, and decreased by approximately 10-15 mmHg under propranolol. No differences between renovascular hypertensive and normotensive baboons were found as a function of drug conditions. Drug effects were not dependent on plasma propranolol concentration. Springer-Verlag, 1992 Beta-adrenergic blocking agents nationallicence Atenolol nationallicence Propranolol nationallicence Renovascular hypertension nationallicence Antihypertensive agents nationallicence Adverse side-effects nationallicence Non-human primates nationallicence Baboons nationallicence Turkkan Jaylan Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, 21224, Baltimore, MD, USA aut Hienz Robert Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, 21224, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 484-488 0033-3158 109:4<484 1992 109 213 https://doi.org/10.1007/BF02247728 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247728 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Turkkan Jaylan Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, 21224, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Hienz Robert Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, 21224, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 484-488 0033-3158 109:4<484 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer