caa a22 4500 469118725 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247712 doi (NATIONALLICENCE)springer-10.1007/BF02247712 Pretreatment with aldosterone or corticosterone blocks the memory-enhancing effects of nimodipine, captopril, CGP 37 849, and strychnine in mice [Elektronische Daten] [Cesare Mondadori, Conrad Gentsch, Bastian Hengerer, Thomas Ducret, Jürgen Borkowski, Amy Racine, Renate Lederer, Albert Haeusler] Oral pretreatment with aldosterone or corticosterone blocked the memory-enhancing effects of the calcium antagonist nimodipine, the ACE inhibitor captopril, the NMDA blocker CGP 37 849, and the glycine antagonist strychnine in a passive-avoidance test in mice. The memory-disturbing effects of phenobarbitone, diazepam, CGP 37 849 and scopolamine were not influenced by the hormonal pretreatment. These findings could indicate the involvement of a steroid-sensitive mechanism in drug-induced improvement of memory. In the light of clinical observations showing elevated cortisol levels in Alzheimer patients, the results might also explain why only a limited number of these patients respond to therapy with memory enhancers. Springer-Verlag, 1992 Memory facilitation nationallicence Memory inhibition nationallicence Corticosteroids nationallicence Captopril nationallicence Nimodipine nationallicence Strychnine nationallicence CGP 37 849 nationallicence Mice nationallicence Mondadori Cesare Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut Gentsch Conrad Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut Hengerer Bastian Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut Ducret Thomas Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut Borkowski Jürgen Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut Racine Amy Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut Lederer Renate Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut Haeusler Albert Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 383-389 0033-3158 109:4<383 1992 109 213 https://doi.org/10.1007/BF02247712 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247712 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mondadori Cesare Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut NATIONALLICENCE 700 1- Gentsch Conrad Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut NATIONALLICENCE 700 1- Hengerer Bastian Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut NATIONALLICENCE 700 1- Ducret Thomas Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut NATIONALLICENCE 700 1- Borkowski Jürgen Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut NATIONALLICENCE 700 1- Racine Amy Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut NATIONALLICENCE 700 1- Lederer Renate Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut NATIONALLICENCE 700 1- Haeusler Albert Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-Basel, Switzerland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 383-389 0033-3158 109:4<383 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer