caa a22 4500 469118733 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247725 doi (NATIONALLICENCE)springer-10.1007/BF02247725 Hyperthermia induced by m -trifluoromethylphenylpiperazine (TFMPP) or m -chlorophenylpiperazine ( m -CPP) in heat-adapted rats [Elektronische Daten] [A. Kłodzińska, E. Chojnacka-Wójcik] TFMPP andm-CPP, non-selective 5-HT agonists, administered in doses of 1-20 mg/kg evoked hyperthermia in rats at a high ambient temperature (28°C). The hyperthermic effect of TFMPP (10 mg/kg) orm-CPP (10 mg/kg) was dose-dependently antagonized by the 5-HT1c and 5-HT2 receptor antagonists mesulergine (0.5-4 mg/kg), ketanserin (0.6-2.5 mg/kg) and ritanserin (0.5-2 mg/kg) and by the non-selective 5-HT antagonist metergoline (0.5-1 mg/kg), or was attenuated by the 5-HT1A, 5-HT2 and dopamine receptor antagonist spiperone (3 mg/kg, but not 0.3 or 1 mg/kg). On the other hand, the 5-HT1A, 5-HT1B andβ adrenoceptor antagonists pindolol (2 mg/kg) and cyanopindolol (2 mg/kg), the 5-HT1A receptor agonist/antagonist ipsapirone (10 and 35 mg/kg) and haloperidol (0.25 and 0.5 mg/kg) showed a tendency towards enhancing the TFMPP- orm-CPP-induced hyperthermia. The 5-HT1A and α1-adrenoceptor antagonist NAN-190 (1-4 mg/kg), the 5-HT3 antagonists tropisetron (0.01-1 mg/kg) and zacopride (0.5 and 1 mg/kg), theβ-blockers betaxolol (8 mg/kg) and ICI 118, 551 (8 mg/kg), which have no affinity for 5-HT receptors and prazosin (1 mg/kg), did not affect the hyperthermic effect of TFMPP orm-CPP. The hyperthermias studied were not modified, in animals with 5-HT lesion produced byp-chloroamphetamine (PCA) either. All the drugs used as putative receptor antagonists, as well as PCA, did not change or decreased (ipsapirone) the body temperature in heat-adapted rats. The obtained results suggest that the hyperthermia induced by TFMPP orm-CPP is mediated by 5-HT2, and maybe also by 5-HT1c receptors — those which are located postsynaptically. Springer-Verlag, 1992 Hyperthermia nationallicence TFMPP nationallicence m -CPP nationallicence 5-HT-receptor antagonists nationallicence Kłodzińska A. Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL-31-343, Kraków, Poland aut Chojnacka-Wójcik E. Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL-31-343, Kraków, Poland aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 466-472 0033-3158 109:4<466 1992 109 213 https://doi.org/10.1007/BF02247725 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247725 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kłodzińska A. Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL-31-343, Kraków, Poland aut NATIONALLICENCE 700 1- Chojnacka-Wójcik E. Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL-31-343, Kraków, Poland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 466-472 0033-3158 109:4<466 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer