caa a22 4500 469118741 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247720 doi (NATIONALLICENCE)springer-10.1007/BF02247720 Scopolamine impairs delayed matching in an olfactory task in rats [Elektronische Daten] [N. Ravel, M. Vigouroux, A. Elaagouby, R. Gervais] The action of the cerebral cholinergic system seems to be important for remembering events over short time intervals. We decided to test this hypothesis in the rat by developing an original model of short term memory based on the olfactory sensory modality which is a major determinant in the animal behaviour. The principle of the experiment was a "delayed match-to-sample” test performed in a classical T maze divided into two compartments. In the first compartment, rats received an odorant stimulation, then, in the second, they had to discriminate between the two arms odorized differently. To receive a food reinforcement, the animals had to enter the arm signaled by the odor presented in the first part of the maze. The test was performed with (Short-term memory condition) or without (Immediate memory condition) a variable delay between the first odor sampling and the discrimination task. Both tests were performed with control and scopolamine-treated animals (0.5, 0.125 and 0.0625 mg/kg IP). An injection of scopolamine (0.5 mg/kg) impaired performances, even when no retention of the odor was required. However, lower doses (0.125, 0.0625 mg/kg) selectively altered performances in the short term memory condition. These results suggest that intact muscarinic transmission is required for an olfactory cue to be used over a short time after its presentation. Springer-Verlag, 1992 Olfaction nationallicence Acetylcholine nationallicence Short-term memory nationallicence Delayed match-to-sample nationallicence Ravel N. Laboratoire de Physiologie Neurosensorielle, Université Lyon I-CNRS URA 180, 43, Bd du 11 Novembre 1918, F-69622, Villeurbanne Cedex, France aut Vigouroux M. Laboratoire de Physiologie Neurosensorielle, Université Lyon I-CNRS URA 180, 43, Bd du 11 Novembre 1918, F-69622, Villeurbanne Cedex, France aut Elaagouby A. Laboratoire de Physiologie Neurosensorielle, Université Lyon I-CNRS URA 180, 43, Bd du 11 Novembre 1918, F-69622, Villeurbanne Cedex, France aut Gervais R. Laboratoire de Physiologie Neurosensorielle, Université Lyon I-CNRS URA 180, 43, Bd du 11 Novembre 1918, F-69622, Villeurbanne Cedex, France aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 439-443 0033-3158 109:4<439 1992 109 213 https://doi.org/10.1007/BF02247720 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247720 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ravel N. Laboratoire de Physiologie Neurosensorielle, Université Lyon I-CNRS URA 180, 43, Bd du 11 Novembre 1918, F-69622, Villeurbanne Cedex, France aut NATIONALLICENCE 700 1- Vigouroux M. Laboratoire de Physiologie Neurosensorielle, Université Lyon I-CNRS URA 180, 43, Bd du 11 Novembre 1918, F-69622, Villeurbanne Cedex, France aut NATIONALLICENCE 700 1- Elaagouby A. Laboratoire de Physiologie Neurosensorielle, Université Lyon I-CNRS URA 180, 43, Bd du 11 Novembre 1918, F-69622, Villeurbanne Cedex, France aut NATIONALLICENCE 700 1- Gervais R. Laboratoire de Physiologie Neurosensorielle, Université Lyon I-CNRS URA 180, 43, Bd du 11 Novembre 1918, F-69622, Villeurbanne Cedex, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 439-443 0033-3158 109:4<439 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer