caa a22 4500 46911875X CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247724 doi (NATIONALLICENCE)springer-10.1007/BF02247724 Effects of the 5-HT3 antagonist ondansetron on benzodiazepine-induced operant behavioural dependence in rats [Elektronische Daten] [Andrew Goudie, Michael Leathley] This study was designed to assess whether rats made tolerant to the suppressant action on Fixed Ratio operant responding of the benzodiazepine (BZ) chlordiazepoxide (CDP) would show behavioural disruption on drug withdrawal—so-called operant behavioural dependence. In addition, the study examined the effects of the 5-HT3 antagonist ondansetron on such operant behavioural dependence. During 42 consecutive days of CDP treatment, at deses escalated from 10 to 30 mg/kg/day, marked tolerance developed to the rate-suppressant action of CDP. On subsequent days, during spontaneous withdrawal, response rates declined significantly by around 30% in animals treated with saline, although some recovery of responding was seen over successive days of withdrawal. Similar reductions in responding followed by recovery were seen in rats treated with the 5-HT3 antagonist ondansetron (0.01-0.1 mg/kg, b.i.d.). These findings demonstrate for the first time that it is possible to use operant procedures to detect spontaneous BZ withdrawal. They also suggest, in agreement with recent studies from this laboratory (Leathley and Goudie 1992), that 5-HT3 antagonists may have relatively limited utility in treating some signs of BZ dependence. Springer-Verlag, 1992 Operant behavioural dependence nationallicence 5-HT3 antagonists nationallicence Ondansetron nationallicence Withdrawal nationallicence Benzodiazepines nationallicence Chlordiazepoxide nationallicence Rats nationallicence Goudie Andrew Department of Psychology, Liverpool University, P.O. Box 147, L69 3BX, Liverpool, UK aut Leathley Michael Department of Psychology, Liverpool University, P.O. Box 147, L69 3BX, Liverpool, UK aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 461-465 0033-3158 109:4<461 1992 109 213 https://doi.org/10.1007/BF02247724 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247724 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goudie Andrew Department of Psychology, Liverpool University, P.O. Box 147, L69 3BX, Liverpool, UK aut NATIONALLICENCE 700 1- Leathley Michael Department of Psychology, Liverpool University, P.O. Box 147, L69 3BX, Liverpool, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 461-465 0033-3158 109:4<461 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer