caa a22 4500 469118768 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247716 doi (NATIONALLICENCE)springer-10.1007/BF02247716 Increased [3H] raclopride binding sites in postmortem brains from schizophrenic violent suicide victims [Elektronische Daten] [Javier Ruiz, Ane Gabilondo, J. Javier Meana, Jesús García-Sevilla] The specific binding of the D2-dopamine receptor antagonist radioligand [3H] raclopride was quantitated in the postmortem caudate and frontal cortex from schizophrenic suicide victims and control subjects. In schizophrenic suicides the density of binding sites (Bmax) was higher (40%,P<0.05) in the caudate, whereas it did not change in the cortex as compared to those in controls. The apparent dissociation constants (K d ) were also found increased both in caudate (24%) and cortex (75%) from schizophrenics, but these apparent decreases in receptor affinity did not reach statistical significance. The mean Bmax value in drug-free schizophrenic suicides (n=3) did not differ from the Bmax value in neuroleptic drug-treated schizophrenics (n=7) but it was found increased in respect to control subjects (n=9). No differences in [3H] raclopride binding were observed between non-schizophrenic suicide victims (n=4) and matched controls (n=4), suggesting that the modifications of D2-dopamine receptors in schizophrenia are not related to suicide. Springer-Verlag, 1992 Schizophrenic suicides nationallicence Human brain nationallicence D2-dopamine receptors nationallicence [3H] raclopride nationallicence Ruiz Javier Department of Pharmacology, University of the Basque Country, Leroa, Bizkaia aut Gabilondo Ane Department of Pharmacology, University of the Basque Country, Leroa, Bizkaia aut Javier Meana J. Department of Pharmacology, University of the Basque Country, Leroa, Bizkaia aut García-Sevilla Jesús Department of Pharmacology, University of the Basque Country, Leroa, Bizkaia aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 410-414 0033-3158 109:4<410 1992 109 213 https://doi.org/10.1007/BF02247716 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247716 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ruiz Javier Department of Pharmacology, University of the Basque Country, Leroa, Bizkaia aut NATIONALLICENCE 700 1- Gabilondo Ane Department of Pharmacology, University of the Basque Country, Leroa, Bizkaia aut NATIONALLICENCE 700 1- Javier Meana J. Department of Pharmacology, University of the Basque Country, Leroa, Bizkaia aut NATIONALLICENCE 700 1- García-Sevilla Jesús Department of Pharmacology, University of the Basque Country, Leroa, Bizkaia aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 410-414 0033-3158 109:4<410 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer