caa a22 4500 469118776 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247729 doi (NATIONALLICENCE)springer-10.1007/BF02247729 Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort [Elektronische Daten] [J. Deijen, E. van der Beek, J. Orlebeke, H. van den Berg] This study evaluates the effects of vitamin B-6 supplementation (20 mg pyridoxine HCL daily for 3 months) on mood and performance in 38 self-supporting healthy men, aged between 70-79 years. Effects were compared with 38 controls who received placebo and were matched for age, plasma pyridoxal-5′-phosphate (PLP) concentration and intelligence score. Before and after drug intervention vitamin B-6 status was determined, and mood and performance were measured by means of a computerized testing system. In addition, the phasic pupil response was measured in order to assess mental effort. Positive effects of vitamin B-6 supplementation were only found with respect to memory, especially concerning long-term memory. In view of the finding that mental performance improvement and Δ PLP values were most strongly correlated within an intermediate range of Δ PLP, it is suggested that cognitive effects are primarily associated with a certain range of vitamin B-6 status increment. The general conclusion is that vitamin B-6 supplementation improves storage of information modestly but significantly. Springer-Verlag, 1992 Vitamin B-6 nationallicence Aging nationallicence Mood nationallicence Memory nationallicence Performance nationallicence Pupil size nationallicence Mental effort nationallicence Deijen J. Department of Psychology, Psychophysiology Division, Vrije Universiteit, De Boelelaan 1111, NL-1081 HV, Amsterdam, The Netherlands aut van der Beek E. Department of Human Nutrition, TNO Toxicology and Nutrition Institute, Postbus 360, NL-3700 AJ, Zeist, The Netherlands aut Orlebeke J. Department of Psychology, Psychophysiology Division, Vrije Universiteit, De Boelelaan 1111, NL-1081 HV, Amsterdam, The Netherlands aut van den Berg H. Department of Human Nutrition, TNO Toxicology and Nutrition Institute, Postbus 360, NL-3700 AJ, Zeist, The Netherlands aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 489-496 0033-3158 109:4<489 1992 109 213 https://doi.org/10.1007/BF02247729 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247729 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Deijen J. Department of Psychology, Psychophysiology Division, Vrije Universiteit, De Boelelaan 1111, NL-1081 HV, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Beek E. Department of Human Nutrition, TNO Toxicology and Nutrition Institute, Postbus 360, NL-3700 AJ, Zeist, The Netherlands aut NATIONALLICENCE 700 1- Orlebeke J. Department of Psychology, Psychophysiology Division, Vrije Universiteit, De Boelelaan 1111, NL-1081 HV, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van den Berg H. Department of Human Nutrition, TNO Toxicology and Nutrition Institute, Postbus 360, NL-3700 AJ, Zeist, The Netherlands aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 489-496 0033-3158 109:4<489 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer