caa a22 4500 469118814 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02247719 doi (NATIONALLICENCE)springer-10.1007/BF02247719 Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline [Elektronische Daten] [Richard Muscat, Mariusz Papp, Paul Willner] Chronic exposure to mild unpredictable stress has previously been found to depress the consumption of palatable sweet solutions. In the present study this effect was reversed by chronic (9 weeks) treatment with the atypical antidepressants, fluoxetine and maprotiline (5 mg/kg/day); the non-antidepressant chlordiazepoxide was ineffective. Stressed animals were also subsensitive to food reward in the place conditioning procedure; however, fluoxetine and maprotiline treated animals showed normal place preference conditioning. Acute pretreatment with raclopride (100 µg/kg) selectively reversed the recovery of sucrose drinking in antidepressant-treated stressed animals. These results extend previous reports of the efficacy of tricyclic antidepressants in this paradigm, and support the hypothesis of a dopaminergic mechanism of antidepressant action. Springer-Verlag, 1992 Stress nationallicence Sucrose drinking nationallicence Place preference conditioning nationallicence Reward nationallicence Fluoxetine nationallicence Maprotiline nationallicence Chlordiazepoxide nationallicence Rats nationallicence Muscat Richard Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Papp Mariusz Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Willner Paul Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Psychopharmacology Springer-Verlag 109/4(1992-12-01), 433-438 0033-3158 109:4<433 1992 109 213 https://doi.org/10.1007/BF02247719 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247719 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Muscat Richard Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Papp Mariusz Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Willner Paul Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/4(1992-12-01), 433-438 0033-3158 109:4<433 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer