caa a22 4500 469118822 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245502 doi (NATIONALLICENCE)springer-10.1007/BF02245502 Effect of 5-HT agonists on rats fed single diets with varying proportions of carbohydrate and protein [Elektronische Daten] [Shuqin Luo, Edmund Li] Low doses of 5-HT agonists have been shown to selectively suppress carbohydrate intake in rats given dietary choices. To investigate further the relationship between dietary macronutrient composition and 5-HT-induced anorexia, the present study examined the effects of three 5-HT agonists on rats fed single isocaloric diets containing varying proportions of carbohydrate (CHO) and protein (PRO). Rats were habituated to eat one of the three diets (73.5% CHO - 10% PRO, 58.5% CHO - 25% PRO or 43.5% CHO - 40% PRO) during the dark period (1900-0700 h). Saline or 5-HT agonists (fluoxetine, RU 24969 and dexfenfluramine) were administered intraperitoneally at 1845 hours, 15 min prior to food access. At the doses used, food intake was significantly affected only during the first hour of eating. All 5-HT agonists caused dose-dependent decreases in food intake (P < 0.01). The magnitude of decrease, however, was significantly influenced by diet composition. Reduction in intake was greatest in rats fed the 73.5% CHO - 10% PRO diet. Thus, rats chronically fed a diet high in carbohydrate content were more sensitive to the anorectic effect of 5-HT agonists than rats fed diets containing moderate to low levels of carbohydrate. Springer-Verlag, 1992 Feeding nationallicence Diet composition nationallicence Carbohydrate nationallicence Dexfenfluramine nationallicence RU 24969 nationallicence Fluoxetine nationallicence Luo Shuqin Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, M5S 1A8, Toronto, Ontario, Canada aut Li Edmund Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, M5S 1A8, Toronto, Ontario, Canada aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 212-216 0033-3158 109:1-2<212 1992 109 213 https://doi.org/10.1007/BF02245502 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245502 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luo Shuqin Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Li Edmund Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 212-216 0033-3158 109:1-2<212 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer