caa a22 4500 469118849 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245495 doi (NATIONALLICENCE)springer-10.1007/BF02245495 Interactions of the β carboline abecarnil with the high pressure neurological syndrome in a primate model [Elektronische Daten] [P. Pearce, M. Halsey, C. MacLean, S. Passingham, J. Pearson, R. Mehta, B. Meldrum, C. Jordan, E. Ward] The neurophysiological interactions between the high pressure neurological syndrome (HPNS) and a newβ carboline, abecarnil, were studied in the nonhuman primatePapio anubis. Abecarnil is a partial agonist at the benzodiazepine site on the GABA/benzodiazepine receptor. Six animals were exposed on two occasions to pressures of 91 ATA in an environment of helium and oxygen. One exposure was pretreated with a total dose of abecarnil 1.0 mg/kg, the other with an equivalent volume of vehicle. Treatment with abecarnil prevented the severe signs of HPNS occurring between 51 and 91 ATA. Onset pressures of the various signs were unaffected. Some signs, e.g. myoclonus, became more frequent when abecarnil was used. A residual protective effect of abecarnil was present 4 weeks after the dose was given, active at pressures less than 71 ATA. Changes with pressure in the EEG were recorded primarily from the frontal cortex, but were also present in the parietal and occipital areas of the left cortex. Amplitude and frequency spectra were calculated and changes with pressure in the four conventional wavebands, plus two others, analysed. The most striking change was the prevention by abecarnil of the pressure-induced 100% increase in alpha wave amplitude in the frontal region. It is concluded that modulation of GABA transmission is important in controlling the expression of HPNS. Springer-Verlag, 1992 HPNS nationallicence Primates nationallicence Abecarnil nationallicence GABA transmission nationallicence EEG nationallicence Behavioural observations nationallicence Pearce P. Anaesthesia/HPNS Research Group, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Halsey M. Anaesthesia/HPNS Research Group, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut MacLean C. Anaesthesia/HPNS Research Group, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Passingham S. Anaesthesia/HPNS Research Group, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Pearson J. Section of Medical Statistics, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Mehta R. Section of Medical Statistics, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Meldrum B. Institute of Psychiatry, De Crespigny Park, SE5, London, UK aut Jordan C. Section of Bioengineering, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Ward E. Anaesthesia/HPNS Research Group, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 163-171 0033-3158 109:1-2<163 1992 109 213 https://doi.org/10.1007/BF02245495 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245495 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pearce P. Anaesthesia/HPNS Research Group, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Halsey M. Anaesthesia/HPNS Research Group, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- MacLean C. Anaesthesia/HPNS Research Group, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Passingham S. Anaesthesia/HPNS Research Group, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Pearson J. Section of Medical Statistics, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Mehta R. Section of Medical Statistics, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Meldrum B. Institute of Psychiatry, De Crespigny Park, SE5, London, UK aut NATIONALLICENCE 700 1- Jordan C. Section of Bioengineering, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Ward E. Anaesthesia/HPNS Research Group, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 163-171 0033-3158 109:1-2<163 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer