caa a22 4500 469118857 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245476 doi (NATIONALLICENCE)springer-10.1007/BF02245476 Pucilowski Olgierd Department of Psychiatry and Skipper Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, School of Medicine, CB# 7175, 27599, Chapel Hill, NC, USA aut Psychopharmacological properties of calcium channel inhibitors [Elektronische Daten] [Olgierd Pucilowski] The previous decade has witnessed a major expansion of knowledge of the role played by voltage-sensitive calcium channels in the function of the central nervous system. Significant progress in the field has been made possible with the broadening use of organic calcium channel inhibitors (CCIs, Ca2+ antagonists), until recently considered almost exclusively as peripherally active antianginal and antiarrhythmic drugs. CCIs, however, do penetrate the blood-brain barrier from the periphery. Autoradiographic studies have established a highly heterogeneous distribution of CCI recognition sites within the brain. The existing evidence suggests that CCIs have marked psychotropic properties. The profile of their central activity is unique and spans a wide range of effects. Nevertheless, question regarding potentially confounding potent peripheral effects of these drugs remain. This paper reviews the psychopharmacology of CCIs, concentrating on preclinical data, but including supportive clinical and biochemical evidence as well. It focuses on these drugs' antidepressant, antidopaminergic (neuroleptic-like), anxiolytic and anticonvulsant effects. CCIs may also modify the reinforcing properties of some addictive drugs. Springer-Verlag, 1992 Ca2+ channel inhibitors nationallicence 1,4-Dihydropyridines nationallicence Antidepressant effect nationallicence Antidopaminergic effect nationallicence Anxiolytic effect nationallicence Anticonvulsant effect nationallicence Drug-induced reinforcement nationallicence Cai : intracellular calcium nationallicence CCI : calcium channel inhibitors nationallicence CNS : central nervous system nationallicence DHP : 1,4-dihydropyridine nationallicence DOPAC : 3,4-dihydrophenylacetic acid nationallicence GABA : gamma-aminobutyric acid nationallicence HVA : homovanilic acid nationallicence NMDA : N-methyl-d-aspartate nationallicence Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 12-29 0033-3158 109:1-2<12 1992 109 213 https://doi.org/10.1007/BF02245476 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245476 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Pucilowski Olgierd Department of Psychiatry and Skipper Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, School of Medicine, CB# 7175, 27599, Chapel Hill, NC, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 12-29 0033-3158 109:1-2<12 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer