caa a22 4500 469118865 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245481 doi (NATIONALLICENCE)springer-10.1007/BF02245481 Tolerance, withdrawal, and supersensitivity to dopamine mediated cues in a drug-drug discrimination [Elektronische Daten] [Robert Barrett, David White, William Caul] Rats were trained to discriminate between 0.25 mg/kg amphetamine (AMPH) and 0.03 mg/kg haloperidol (HAL) in a two-lever drug discrimination task. In order to test for a drug-induced withdrawal state, animals were assigned to one of three chronic treatment groups and given injections of AMPH, HAL, or distilled water (DW) for 10 consecutive days. Subjects from each treatment condition were then tested at 24, 48, or 72 h after the final injection. At the 24 h retest interval, subjects injected with AMPH responded as though administered an acute dose of HAL (0.028 mg/kg) and subjects injected with chronic HAL responded as though administered an acute dose of AMPH (0.15 mg/kg). By 72 h choice behavior had returned to pretreatment values. To determine whether the rebound observed after 10 days of drug treatment was present after a single injection, independent groups of subjects were injected with single doses of either 10 mg/kg AMPH or 1.0 mg/kg HAL and then retested from 4 h to 48 h later. Single doses of both AMPH and HAL produced significant rebounds that peaked between 20 h (AMPH) and 24 h (HAL) following administration. In a third experiment, animals were tested with or without acute doses of drug following pretreatment with either HAL or AMPH. Receptor supersensitivity accounts for the tolerance observed to HAL 24 h after treatment with 1.0 mg/kg HAL, whereas receptor subsensitivity accounts for the tolerance observed 20 h after treatment with 10 mg/kg AMPH. Springer-Verlag, 1992 Amphetamine nationallicence Haloperidol nationallicence Drug discrimination nationallicence Supersensitivity nationallicence Tolerance nationallicence Withdrawal nationallicence Barrett Robert Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University, 1310 24th Avenue South, 37203, Nashville, TN, USA aut White David Department of Psychology, Vanderbilt University, Wilson Hall, 37240, Nashville, TN, USA aut Caul William Department of Psychology, Vanderbilt University, Wilson Hall, 37240, Nashville, TN, USA aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 63-67 0033-3158 109:1-2<63 1992 109 213 https://doi.org/10.1007/BF02245481 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245481 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barrett Robert Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University, 1310 24th Avenue South, 37203, Nashville, TN, USA aut NATIONALLICENCE 700 1- White David Department of Psychology, Vanderbilt University, Wilson Hall, 37240, Nashville, TN, USA aut NATIONALLICENCE 700 1- Caul William Department of Psychology, Vanderbilt University, Wilson Hall, 37240, Nashville, TN, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 63-67 0033-3158 109:1-2<63 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer