caa a22 4500 469118881 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245511 doi (NATIONALLICENCE)springer-10.1007/BF02245511 Evidence that the large neutral amino acid l -valine decreases electrically-evoked release of 5-HT in rat hippocampus in vivo [Elektronische Daten] [S. Gartside, P. Cowen, T. Sharp] l-Valine competes with tryptophan for transport into the brain and has previously been shown to decrease brain 5-HT synthesis. In the present study, the effect ofl-valine on electrically evoked hippocampal 5-HT release was determined in the anaesthetized rat using microdialysis. In control animals two electrical stimulations of the dorsal raphe nucleus 120 min apart (S1 and S2, respectively) released similar amounts of 5-HT. In contrast, in animals which receivedl-valine (200 mg/kg) between stimulations, S2 released a significantly smaller amount of 5-HT than did S1, although basal 5-HT release was unchanged. The data demonstrate thatl-valine decreases the electrically-evoked release of 5-HT in hippocampus in vivo. Springer-Verlag, 1992 5-HT release nationallicence 5-HT synthesis nationallicence Amino acids nationallicence l -tryptophan nationallicence l -valine nationallicence Gartside S. Radcliffe Infirmary, MRC Unit of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut Cowen P. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut Sharp T. Radcliffe Infirmary, MRC Unit of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 251-253 0033-3158 109:1-2<251 1992 109 213 https://doi.org/10.1007/BF02245511 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245511 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gartside S. Radcliffe Infirmary, MRC Unit of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut NATIONALLICENCE 700 1- Cowen P. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut NATIONALLICENCE 700 1- Sharp T. Radcliffe Infirmary, MRC Unit of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 251-253 0033-3158 109:1-2<251 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer