caa a22 4500 46911889X CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245490 doi (NATIONALLICENCE)springer-10.1007/BF02245490 Comparative effects of alpha-2 receptor agents and THA on the performance of adult and aged rats in the delayed non-matching to position task [Elektronische Daten] [Jouni Sirviö, Maija Harju, Paavo Riekkinen Jr, Antti Haapalinna, Paavo Riekkinen] The present study investigated the effects of dexmedetomidine (an alpha-2 adrenoceptor agonist), atipamezole (an alpha-2 adrenoceptor antagonist) and tacrine (an inhibitor of acetylcholinesterase) on the performance of adult and aged rats in a delayed non-matching to position task assessing spatial short-term memory. Most of the aged rats were impaired in the pretraining phases and in the acquisition of the non-delayed version of the task. After a substantial training period of the delayed version of the task, both adult and aged rats reached their asymptotic level of performance. Both adult and aged rats showed a decline in the percent correct responses at the longest delays in this task, and a delay independent decrease in the percent correct responses across the delays (0-30 s) was found in the group of aged rats (25-month-old) as compared to the adults (10-month-old). Dexmedetomidine (0.3, 1.0 or 3.0 µg/kg), atipamezole (0.03, 0.3 or 3.0 mg/kg) and tacrine (1.0 or 3.0 mg/kg) did not increase the percent correct responses in adult or aged rats. The highest doses of dexmedetomidine and tacrine decreased behavioural activity of rats during this short-term memory testing. Atipamezole (0.03 mg/kg) increased behavioural activity of rats. The results suggest that acute, systemic administrations of alpha-2 drugs or an anticholinesterase do not improve short-term memory in rats. Springer-Verlag, 1992 Short-term memory nationallicence Aging nationallicence Noradrenergic system nationallicence Alpha-2 adrenoceptors nationallicence Cholinergic system nationallicence Rat nationallicence Sirviö Jouni Department of Neurology, University of Kuopio, P. O. Box 1627, SF-70211, Kuopio, Finland aut Harju Maija Department of Neurology, University of Kuopio, P. O. Box 1627, SF-70211, Kuopio, Finland aut Riekkinen Jr Paavo Department of Neurology, University of Kuopio, P. O. Box 1627, SF-70211, Kuopio, Finland aut Haapalinna Antti Orion Corporation Farmos, R&D Pharmaceuticals, SF-Turka, Finland aut Riekkinen Paavo Department of Neurology, University of Kuopio, P. O. Box 1627, SF-70211, Kuopio, Finland aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 127-133 0033-3158 109:1-2<127 1992 109 213 https://doi.org/10.1007/BF02245490 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245490 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sirviö Jouni Department of Neurology, University of Kuopio, P. O. Box 1627, SF-70211, Kuopio, Finland aut NATIONALLICENCE 700 1- Harju Maija Department of Neurology, University of Kuopio, P. O. Box 1627, SF-70211, Kuopio, Finland aut NATIONALLICENCE 700 1- Riekkinen Jr Paavo Department of Neurology, University of Kuopio, P. O. Box 1627, SF-70211, Kuopio, Finland aut NATIONALLICENCE 700 1- Haapalinna Antti Orion Corporation Farmos, R&D Pharmaceuticals, SF-Turka, Finland aut NATIONALLICENCE 700 1- Riekkinen Paavo Department of Neurology, University of Kuopio, P. O. Box 1627, SF-70211, Kuopio, Finland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 127-133 0033-3158 109:1-2<127 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer