caa a22 4500 469118903 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245479 doi (NATIONALLICENCE)springer-10.1007/BF02245479 Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to MPTP-treated common marmosets [Elektronische Daten] [Peter-A. Löschmann, Lance Smith, Klaus Lange, Peter Jähnig, Peter Jenner, C. Marsden] The ability of selective D-1 agonist and antagonist drugs to alter motor deficits and locomotor activity was studied in MPTP-treated common marmosets. Both the D-2 agonist quinpirole and the mixed D-1/D-2 agonist apomorphine reversed the motor impairments and induced locomotor activity. The D-1 antagonist SCH 23390 and the D-2 antagonist raclopride given alone further reduced motor function in MPTP-treated animals. The actions of quinpirole were potently and completely inhibited by raclopride but only partially and inconsistently by SCH 23390. In contrast, the effects of apomorphine were markedly but incompletely inhibited by both raclopride and SCH 23390. The D-1 agonist SKF 38393 alone caused a dose related reduction in motor activity. SKF 38393 weakly and partially inhibited the improvements in motor function produced by quinpirole but had a more pronounced effect on apomorphine induced motor activity. The induction of motor activity in MPTP treated common marmosets may separately involve both D-1 and D-2 receptors. Comparison with our previous data on the effect of the same drugs in normal common marmosets provides some evidence for a breakdown of linkage between D-1 and D-2 systems following MPTP treatment. The actions of SKF 38393 in MPTP-treated common marmosets contrasts with its ability to induce behavioural activation and a facilitation of D-2 mediated behaviour in rodents. SKF 38393 may not be the compound with which to delineate the role of D-1 receptors in primates. Springer-Verlag, 1992 Raclopride nationallicence Quinpirole nationallicence SCH 23390 nationallicence Apomorphine nationallicence Marmosets nationallicence Dopamine receptors nationallicence Löschmann Peter-A Research Laboratories of Schering AG, W-1000, Berlin 65, Federal Republic of Germany aut Smith Lance Parkinson's Disease Society Experimental Research Laboratories, Pharmacology Group, Biomedical Sciences Division, King's College, Manresa Road, SW3 6LX, London, UK aut Lange Klaus Parkinson's Disease Society Experimental Research Laboratories, Pharmacology Group, Biomedical Sciences Division, King's College, Manresa Road, SW3 6LX, London, UK aut Jähnig Peter A F B Comstat Berlin, Europacenter, W-1000, Berlin 15, Federal Republic of Germany aut Jenner Peter Parkinson's Disease Society Experimental Research Laboratories, Pharmacology Group, Biomedical Sciences Division, King's College, Manresa Road, SW3 6LX, London, UK aut Marsden C. University Department of Clinical Neurology, Institute of Neurology, The National Hospital, Queen Square, WC1, London, UK aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 49-56 0033-3158 109:1-2<49 1992 109 213 https://doi.org/10.1007/BF02245479 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245479 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Löschmann Peter-A Research Laboratories of Schering AG, W-1000, Berlin 65, Federal Republic of Germany aut NATIONALLICENCE 700 1- Smith Lance Parkinson's Disease Society Experimental Research Laboratories, Pharmacology Group, Biomedical Sciences Division, King's College, Manresa Road, SW3 6LX, London, UK aut NATIONALLICENCE 700 1- Lange Klaus Parkinson's Disease Society Experimental Research Laboratories, Pharmacology Group, Biomedical Sciences Division, King's College, Manresa Road, SW3 6LX, London, UK aut NATIONALLICENCE 700 1- Jähnig Peter A F B Comstat Berlin, Europacenter, W-1000, Berlin 15, Federal Republic of Germany aut NATIONALLICENCE 700 1- Jenner Peter Parkinson's Disease Society Experimental Research Laboratories, Pharmacology Group, Biomedical Sciences Division, King's College, Manresa Road, SW3 6LX, London, UK aut NATIONALLICENCE 700 1- Marsden C. University Department of Clinical Neurology, Institute of Neurology, The National Hospital, Queen Square, WC1, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 49-56 0033-3158 109:1-2<49 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 468452877 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer