caa a22 4500 469118911 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245501 doi (NATIONALLICENCE)springer-10.1007/BF02245501 Dissociation between the effects of benzodiazepine receptor agonists on behavioral vigilance and responsivity [Elektronische Daten] [Paul Dudchenko, Brooke Paul, Martin Sarter] The effects of benzodiazepine receptor (BZR) full agonists chlordiazepoxide and midazolam, and the partial agonistβ-carboline ZK 91 296 on the rat's performance in a simple reaction time paradigm were examined. This task required the animals to respond to a rarely and unpredictably occurring brief (50 ms) visual stimulus. Non-parametric measures of signal sensitivity and response bias derived from signal-detection theory were used as a basis for the dissociation between the effects of these drugs on attentional abilities and general responsivity. The dose-dependent effects of midazolam (0.1-3.13 mg/kg) on signal sensitivity and general responsivity occurred in parallel. In contrast, the effects of chlordiazepoxide (1.56-12.5 mg/kg) on signal sensitivity were largely independent from effects on response bias. The partial agonist ZK 91 296 (0.39-25 mg/kg) in general had little effect on performance. The effects of the highest doses of chlordiazepoxide and midazolam were reversed by the co-administration of the BZR antagonist Ro15-1788 (15 mg/kg). Additionally, extension of the stimulus presentation time to 500 ms decreased the magnitude of the effect of chlordiazepoxide on signal sensitivity. These results support the hypothesis that BZR agonist-induced disruption of attentional abilities is not necessarily confounded by effects on general responsivity or sedation, and thus may represent a discrete pharmacological property of BZR-agonists. Springer-Verlag, 1992 Chloridazepoxide nationallicence Midazolam nationallicence ZK 91 296 nationallicence Ro15-1788 nationallicence Vigilance nationallicence Attention nationallicence Dudchenko Paul Department of Psychology and Neuroscience Program, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut Paul Brooke Department of Psychology and Neuroscience Program, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut Sarter Martin Department of Psychology and Neuroscience Program, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 203-211 0033-3158 109:1-2<203 1992 109 213 https://doi.org/10.1007/BF02245501 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245501 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dudchenko Paul Department of Psychology and Neuroscience Program, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut NATIONALLICENCE 700 1- Paul Brooke Department of Psychology and Neuroscience Program, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut NATIONALLICENCE 700 1- Sarter Martin Department of Psychology and Neuroscience Program, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 203-211 0033-3158 109:1-2<203 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer