caa a22 4500 46911892X CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245499 doi (NATIONALLICENCE)springer-10.1007/BF02245499 Neonatal administration of a GABA-T inhibitor alters central GABAA receptor mechanisms and alcohol drinking in adult rats [Elektronische Daten] [T. Taira, T. Porkka-Heiskanen, E. Korpi] Long-term effects of chronic treatment with a GABA-T (GABA-transaminase) inhibitor, ethanolamine O-sulphate (EOS) (200 mg/kg/day for the postnatal days 3-21) on the binding parameters of GABAA receptors, hypothalamic monoamines and subsequent behavior were studied in Wistar rats. At the age of 1 month, EOS-treated rats showed reduced activity in the open-field and, at the age of 4 months, their voluntary alcohol consumption was increased. No changes were seen in Porsolt's swim test or in the plus-maze test. Weight gain was significantly retarded in EOS-treated rats. Maximal stimulation of [3H] flunitrazepam binding by GABA was decreased in the cerebral cortex and the EC50-value for the GABA stimulation increased in the hippocampus in the EOS rats at the age of 4 months. EOS treatment did not alter the cerebellar diazepam sensitive and insensitive binding components of the imidazobenzodiazepine [3H]Ro 15-4513. No changes were observed in the hypothalamic monoamine concentrations. The results are in agreement with the idea that GABA-T inhibitor treatment permanently alters GABAA mechanisms. Moreover, altering the CNS GABA level during development increases adult alcohol intake in rat. Springer-Verlag, 1992 Alcohol intake nationallicence Development nationallicence Ethanolamine O-sulphate nationallicence GABAA receptors nationallicence Postnatal nationallicence Rat nationallicence Taira T. Department of Physiology, University of Helsinki, Siltavuorenpenger 20 J, SF-00170, Helsinki, Finland aut Porkka-Heiskanen T. Department of Physiology, University of Helsinki, Siltavuorenpenger 20 J, SF-00170, Helsinki, Finland aut Korpi E. Biomedical Research Center, Alko Ltd., P.O. Box 350, SF-00101, Helsinki, Finland aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 191-197 0033-3158 109:1-2<191 1992 109 213 https://doi.org/10.1007/BF02245499 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245499 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Taira T. Department of Physiology, University of Helsinki, Siltavuorenpenger 20 J, SF-00170, Helsinki, Finland aut NATIONALLICENCE 700 1- Porkka-Heiskanen T. Department of Physiology, University of Helsinki, Siltavuorenpenger 20 J, SF-00170, Helsinki, Finland aut NATIONALLICENCE 700 1- Korpi E. Biomedical Research Center, Alko Ltd., P.O. Box 350, SF-00101, Helsinki, Finland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 191-197 0033-3158 109:1-2<191 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer