caa a22 4500 469118938 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245493 doi (NATIONALLICENCE)springer-10.1007/BF02245493 Effect of acute and chronic benzodiazepines on plasma GABA in anxious patients and controls [Elektronische Daten] [Peter Roy-Byrne, Deborah Cowley, Daniel Hommer, David Greenblatt, Gerald Kramer, Frederick Petty] The acute effects of diazepam on plasma GABA were determined in 18 patients with panic disorder, 13 patients with generalized anxiety disorder and 20 healthy controls. All subjects were benzodiazepine-naive. Four logarithmically increasing doses of diazepam/placebo were administered intravenously at 15-min intervals on 2 separate days. Plasma GABA was measured at baseline and 3 min after the highest dose of diazepam/placebo. There was an overall decrease in plasma GABA that was significantly greater following diazepam compared with placebo, but no group differences in response. In a separate group of 18 panic disorder patients receiving chronic benzodiazepine treatment with alprazolam, the same diazepam infusion procedure (no placebo day) produced decreases in plasma GABA similar to those seen in the untreated panic disorder patients. The clinical and physiologic implications of these findings are discussed. Springer-Verlag, 1992 Benzodiazepines nationallicence Plasma GABA nationallicence Anxiety nationallicence Roy-Byrne Peter Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 98195, Seattle, WA, USA aut Cowley Deborah Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 98195, Seattle, WA, USA aut Hommer Daniel Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 98195, Seattle, WA, USA aut Greenblatt David Tufts University School of Medicine, Boston, MA, USA aut Kramer Gerald Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas, TX, USA aut Petty Frederick Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas, TX, USA aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 153-156 0033-3158 109:1-2<153 1992 109 213 https://doi.org/10.1007/BF02245493 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245493 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roy-Byrne Peter Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 98195, Seattle, WA, USA aut NATIONALLICENCE 700 1- Cowley Deborah Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 98195, Seattle, WA, USA aut NATIONALLICENCE 700 1- Hommer Daniel Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 98195, Seattle, WA, USA aut NATIONALLICENCE 700 1- Greenblatt David Tufts University School of Medicine, Boston, MA, USA aut NATIONALLICENCE 700 1- Kramer Gerald Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas, TX, USA aut NATIONALLICENCE 700 1- Petty Frederick Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas, TX, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 153-156 0033-3158 109:1-2<153 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer