caa a22 4500 469118954 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245494 doi (NATIONALLICENCE)springer-10.1007/BF02245494 Roles of δ and μ opioid receptors in mediating the effects of enkephalins on avoidance conditioning [Elektronische Daten] [Gery Schulteis, Joe Martinez Jr] The effects on one-way active avoidance conditioning of pre-training, systemic administration of the selective μ-receptor agonist [d-Ala2,N-Me-Phe4, Glyol]enkephalin (DAGO), and the selective μ-receptor antagonist (d-Phe-Cys-Tyr-d-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP), were determined in Swiss-Webster mice. A low dose of DAGO (0.92 µg/kg) moderately enhanced avoidance acquisition, whereas a 100 µg/kg dose of CTOP more dramatically impaired acquisition. However, the avoidance-enhancing dose of DAGO significantly increased locomotor activity as measured in a separate group of mice in the avoidance chamber, and the avoidance-impairing dose of CTOP significantly decreased activity. Under these same training conditions, earlier studies (Schulteis et al. 1988; Schulteis and Martinez 1990) demonstrated that enkephalins impaired avoidance learning, and selectiveδ-receptor antagonists such as ICI 174,864 enhanced learning; in contrast to the present study, both of these effects were dissociated from performance effects such as alterations in locomotor activity. Taken together, the results suggested that the effects of enkephalins were mediated by theδ-, but not μ-, class of opioid receptor. Springer-Verlag, 1992 Opioid peptides nationallicence Opioid receptors nationallicence Selective agonists nationallicence Selective antagonists nationallicence Mu receptor nationallicence Delta receptor nationallicence Active avoidance conditioning nationallicence Learning nationallicence Mice nationallicence Schulteis Gery Department of Psychology, University of California, 94720, Berkeley, CA, USA aut Martinez Jr Joe Department of Psychology, University of California, 94720, Berkeley, CA, USA aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 157-162 0033-3158 109:1-2<157 1992 109 213 https://doi.org/10.1007/BF02245494 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245494 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schulteis Gery Department of Psychology, University of California, 94720, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Martinez Jr Joe Department of Psychology, University of California, 94720, Berkeley, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 157-162 0033-3158 109:1-2<157 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer