caa a22 4500 469118962 CHVBK 20180323133132.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245504 doi (NATIONALLICENCE)springer-10.1007/BF02245504 Attenuation of muscarinic receptor blockade-induced impairment of spatial delayed alternation performance by the triazole MDL 26,479 [Elektronische Daten] [L. Holley, P. Dudchenko, M. Sarter] The interactions between the effects of MDL 26,479 (0.1, 0.39, 1.56, 6.25 mg/kg; IP) and the muscarinic antagonist scopolamine (0.03, 0.1 mg/kg; IP) on the performance of rats in a delayed alternation task (retention intervals: 2, 4, 8, 16, 32 s) were examined. Scopolamine dose-dependently reduced the relative number of correct responses and interacted with the effects of the length of retention intervals. MDL 26,479 did not affect correct responding but attenuated the behavioral impairments produced by scopolamine. Although this task did not explicitly exclude the possibility that the animals acquired mediational response strategies, and although the effects of scopolamine appeared to interfere with the execution of these strategies, to a major extent, the attenuative effects of MDL 26,479 were not related to its effects on mediational strategies. Thus, it is concluded that administration of MDL 26,479 mainly resulted in a re-establishment of the animals' ability to memorize and/or to recall the information required to exert correct responses. Springer-Verlag, 1992 Spatial alteration behavior nationallicence Working memory nationallicence Rehearsal nationallicence Scopolamine nationallicence Holley L. Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut Dudchenko P. Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut Sarter M. Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 223-230 0033-3158 109:1-2<223 1992 109 213 https://doi.org/10.1007/BF02245504 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245504 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holley L. Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut NATIONALLICENCE 700 1- Dudchenko P. Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut NATIONALLICENCE 700 1- Sarter M. Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 223-230 0033-3158 109:1-2<223 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer