caa a22 4500 469119004 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245508 doi (NATIONALLICENCE)springer-10.1007/BF02245508 Selective effects of the D1 dopamine receptor agonist, SKF 38393, on behavior maintained by cocaine injection in squirrel monkeys [Elektronische Daten] [Jonathan Katz, Jeffrey Witkin] The effects of the dopamine receptor D1 partial agonist, SKF 38393, on behavior maintained by cocaine was assessed in squirrel monkeys (Saimiri sciureus). One group of subjects was trained to press a key under a fixed-ratio 30-response schedule of cocaine injection; when green stimulus lamps were illuminated each 30th response produced an injection (17 µg/kg) followed by a 1-min period during which the lights were out and responses had no scheduled consequences. Another group of squirrel monkeys was trained under an identical schedule with food reinforcement. SKF 38393 produced dose-related decreases in rates of responding maintained by either cocaine injection or food presentation. Rates of responding maintained by cocaine were decreased to a greater extent than those maintained by food. The ED50 value for SKF 38393 for responding maintained by cocaine was 2.53 mg/kg (95% CL: 1.22-5.23), whereas that value was 15.63 mg/kg (95% CL: 2.83-86.33) for responding maintained by food. Rates of responding maintained by cocaine were an inverted-U-shaped function of dose. Pretreatment with 3.0 mg/kg SKF 38393 shifted the ascending limb of the cocaine dose-effect curve to the right. These findings suggest that indirect D1-receptor activation plays a role in the reinforcing effects of cocaine, and that drugs acting at D1 receptors may show promise as therapeutic agents in the treatment of cocaine abuse. Springer-Verlag, 1992 Cocaine nationallicence Self administration nationallicence D1 dopamine agonists nationallicence SKF 38393 nationallicence Reinforcement nationallicence Squirrel monkeys nationallicence Katz Jonathan Psychobiology Laboratory, Preclinical Pharmacology Branch, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut Witkin Jeffrey Psychobiology Laboratory, Preclinical Pharmacology Branch, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 241-244 0033-3158 109:1-2<241 1992 109 213 https://doi.org/10.1007/BF02245508 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245508 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Katz Jonathan Psychobiology Laboratory, Preclinical Pharmacology Branch, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Witkin Jeffrey Psychobiology Laboratory, Preclinical Pharmacology Branch, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 241-244 0033-3158 109:1-2<241 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer