caa a22 4500 469119039 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245503 doi (NATIONALLICENCE)springer-10.1007/BF02245503 Context-drug pairings enhance tolerance to ethanol-induced disruption of operant responding [Elektronische Daten] [Christopher Cunningham, Steven Losli, Fred Risinger] Much of the research implicating learning in the development of tolerance to ethanol-induced impairment has used an experimental design in which different groups receive drug either before or after an opportunity to perform an instrumental or operant task. The stronger tolerance observed in subjects who perform while intoxicated is most often attributed to the reinforced practice of a learned compensatory response. Using an experimental procedure modeled after Chen (1979), the present study examined an alternative theoretical basis for tolerance in the before-versus-after design. Specifically, the effects of Pavlovian context-drug pairings were assessed under circumstances that precluded reinforced practice of the operant response. Three groups of food-deprived rats were initially trained to barpress for sucrose on an FR15 schedule. After 30 sessions, the bar was retracted and the dipper was covered for a 3-day tolerance acquisition phase. During this phase, each group received an IP injection 15 min before and 45 min after each session. The Paired group received ethanol (1.2 g/kg) before and saline after the session, thus pairing ethanol with cues of the test chamber. The Unpaired group received saline before and ethanol after the session, while the No-Drug group always received saline. During a final test phase, all groups received ethanol (1.5 g/kg) before access to sucrose on the FR schedule. The Paired group completed the first FR15 sequence more rapidly than either control group, indicating that context-ethanol pairings enhanced tolerance to the drug's disruptive effect on the initiation of operant responding. However, there was little evidence of conditioned stimulus control over tolerance to ethanol's thermal effect. Overall, these data suggest that stimulus-drug contingencies occurring in operant procedures may play an important role in development of tolerance to ethanol's behavioral effects. Springer-Verlag, 1992 Behavioral tolerance nationallicence Contingent tolerance nationallicence Conditioned tolerance nationallicence Pavlovian conditioning nationallicence Operant schedule nationallicence Body temperature nationallicence Hypothermia nationallicence Ethanol nationallicence Rats nationallicence Cunningham Christopher Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Road, 97201-3098, Portland, OR, USA aut Losli Steven Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Road, 97201-3098, Portland, OR, USA aut Risinger Fred Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Road, 97201-3098, Portland, OR, USA aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 217-222 0033-3158 109:1-2<217 1992 109 213 https://doi.org/10.1007/BF02245503 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245503 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cunningham Christopher Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Road, 97201-3098, Portland, OR, USA aut NATIONALLICENCE 700 1- Losli Steven Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Road, 97201-3098, Portland, OR, USA aut NATIONALLICENCE 700 1- Risinger Fred Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Road, 97201-3098, Portland, OR, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 217-222 0033-3158 109:1-2<217 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer