caa a22 4500 469119047 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245496 doi (NATIONALLICENCE)springer-10.1007/BF02245496 Effect of number of conditioning trials on the development of associative tolerance to morphine [Elektronische Daten] [Antonio Cepeda-Benito, Stephen Tiffany] The acquisition of associative tolerance to the analgesic effects of morphine was investigated by giving independent groups of rats 1, 3, 5, 8, 14, 20, or 30 administrations of drug either explicitly paired or unpaired with a distinctive context. Tolerance, assessed on a tail-flick device using dose-response curve (DRC) methodology, developed more rapidly and reached greater magnitude when morphine and the distinctive context were explicitly paired rather than explicitly unpaired. Tolerance magnitude in both conditions reached a maximum at eight conditioning sessions. It is argued that the tolerance found in both treatment groups was associatively controlled. The function of handling and injection cues as conditioned stimuli, and the deleterious effects of latent inhibition and partial reinforcement on conditioned excitation and conditioned inhibition are discussed. Springer-Verlag, 1992 Conditioning nationallicence Tolerance nationallicence Morphine nationallicence Tailflick nationallicence Dose-response curves nationallicence Cepeda-Benito Antonio Department of Psychological Sciences, Purdue University, 47907, West Lafayette, IN, USA aut Tiffany Stephen Department of Psychological Sciences, Purdue University, 47907, West Lafayette, IN, USA aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 172-176 0033-3158 109:1-2<172 1992 109 213 https://doi.org/10.1007/BF02245496 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245496 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cepeda-Benito Antonio Department of Psychological Sciences, Purdue University, 47907, West Lafayette, IN, USA aut NATIONALLICENCE 700 1- Tiffany Stephen Department of Psychological Sciences, Purdue University, 47907, West Lafayette, IN, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 172-176 0033-3158 109:1-2<172 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer