caa a22 4500 469119055 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245510 doi (NATIONALLICENCE)springer-10.1007/BF02245510 Effects of chronic nicotine and haloperidol administration on muscarinic receptor-mediated phosphoinositide turnover in rat brain slices [Elektronische Daten] [Rena Li, Lauren Wing, Darrell Kirch, Richard Wyatt, De-Maw Chuang] Muscarinic receptor-mediated phosphoinositide (PI) turnover in rat brain slices was assessed after chronic administration of nicotine (12 mg/kg/day) or haloperidol decanoate (1.5 mg/kg/day), either alone or in combination, for 6 weeks. Nicotine alone did not significantly alter carbachol-induced inositol monophosphate (IP1) accumulation in the frontal cortex, but did result in a significant increase in the hippocampus, and in a decrease in the striatum. Haloperidol alone attenuated carbachol-stimulated IP1 accumulation in all three brain regions. Chronic treatment with combined nicotine and haloperidol resulted in no significant change in carbachol-sensitive IP1 accumulation in either the frontal cortex or hippocampus but did result in a decrease in the striatum. The results suggest significant cross-talk between cholinergic and dopaminergic systems in affecting PI metabolism. Springer-Verlag, 1992 Nicotine nationallicence Haloperidol nationallicence Phosphoinositide turnover nationallicence Muscarinic receptor nationallicence Li Rena Neuropsychiatry Branch, National Institute of Mental Health, Neuroscience Center at Saint Elizabeths, 20032, Washington, DC, USA aut Wing Lauren Neuropsychiatry Branch, National Institute of Mental Health, Neuroscience Center at Saint Elizabeths, 20032, Washington, DC, USA aut Kirch Darrell Neuropsychiatry Branch, National Institute of Mental Health, Neuroscience Center at Saint Elizabeths, 20032, Washington, DC, USA aut Wyatt Richard Neuropsychiatry Branch, National Institute of Mental Health, Neuroscience Center at Saint Elizabeths, 20032, Washington, DC, USA aut Chuang De-Maw Biological Psychiatry Branch, National Institute of Mental Health, 20892, Bethesda, MD, USA aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 248-250 0033-3158 109:1-2<248 1992 109 213 https://doi.org/10.1007/BF02245510 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245510 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Rena Neuropsychiatry Branch, National Institute of Mental Health, Neuroscience Center at Saint Elizabeths, 20032, Washington, DC, USA aut NATIONALLICENCE 700 1- Wing Lauren Neuropsychiatry Branch, National Institute of Mental Health, Neuroscience Center at Saint Elizabeths, 20032, Washington, DC, USA aut NATIONALLICENCE 700 1- Kirch Darrell Neuropsychiatry Branch, National Institute of Mental Health, Neuroscience Center at Saint Elizabeths, 20032, Washington, DC, USA aut NATIONALLICENCE 700 1- Wyatt Richard Neuropsychiatry Branch, National Institute of Mental Health, Neuroscience Center at Saint Elizabeths, 20032, Washington, DC, USA aut NATIONALLICENCE 700 1- Chuang De-Maw Biological Psychiatry Branch, National Institute of Mental Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 248-250 0033-3158 109:1-2<248 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer